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- NCIT_C91068 IAO_0000115 "The orally bioavailable mesylate salt of a synthetic prodrug targeting the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 inhibitor SNX-5422 is rapidly converted to SNX-2112, which accumulates more readily in tumors relative to normal tissues. SNX-2112 inhibits Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation or immune responses." @default.
- NCIT_C91068 NCIT_A32 NCIT_C1909 @default.
- NCIT_C91068 NCIT_A7 NCIT_C17766 @default.
- NCIT_C91068 NCIT_NHC0 "C91068" @default.
- NCIT_C91068 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C91068 NCIT_P107 "Hsp90 Inhibitor SNX-5422 Mesylate" @default.
- NCIT_C91068 NCIT_P108 "Hsp90 Inhibitor SNX-5422 Mesylate" @default.
- NCIT_C91068 NCIT_P207 "C3253587" @default.
- NCIT_C91068 NCIT_P210 "1173111-67-5" @default.
- NCIT_C91068 NCIT_P319 "K3BO8V06RM" @default.
- NCIT_C91068 NCIT_P322 "CTRP" @default.
- NCIT_C91068 NCIT_P322 "FDA" @default.
- NCIT_C91068 NCIT_P322 "GDC" @default.
- NCIT_C91068 NCIT_P325 "A substance being studied in the treatment of cancer. SNX-5422 mesylate blocks a protein needed for cells to grow and may kill cancer cells. It is a type of heat shock protein 90 inhibitor." @default.
- NCIT_C91068 NCIT_P329 "590712" @default.
- NCIT_C91068 NCIT_P330 "590712" @default.
- NCIT_C91068 NCIT_P375 "Hsp90 Inhibitor SNX-5422 Mesylate" @default.
- NCIT_C91068 NCIT_P399 "590712" @default.
- NCIT_C91068 NCIT_R125 NCIT_C17828 @default.
- NCIT_C91068 NCIT_R125 NCIT_C20150 @default.
- NCIT_C91068 NCIT_R125 NCIT_C20480 @default.
- NCIT_C91068 NCIT_R125 NCIT_C40715 @default.
- NCIT_C91068 NCIT_R125 NCIT_C41515 @default.
- NCIT_C91068 NCIT_R125 NCIT_C51037 @default.
- NCIT_C91068 normalizedInformationContent "100" @default.
- NCIT_C91068 referenceCount "1" @default.
- NCIT_C91068 hasExactSynonym "Hsp90 Inhibitor SNX-5422 Mesylate" @default.
- NCIT_C91068 hasExactSynonym "SNX-5422 MESYLATE" @default.
- NCIT_C91068 hasExactSynonym "SNX-5422 Mesylate" @default.
- NCIT_C91068 hasExactSynonym "SNX-5422 mesylate" @default.
- NCIT_C91068 hasExactSynonym "SNX-5422" @default.
- NCIT_C91068 inSubset NCIT_C116977 @default.
- NCIT_C91068 inSubset NCIT_C116978 @default.
- NCIT_C91068 inSubset NCIT_C128784 @default.
- NCIT_C91068 inSubset NCIT_C157711 @default.
- NCIT_C91068 inSubset NCIT_C157712 @default.
- NCIT_C91068 inSubset NCIT_C176424 @default.
- NCIT_C91068 inSubset NCIT_C177537 @default.
- NCIT_C91068 inSubset NCIT_C63923 @default.
- NCIT_C91068 type Class @default.
- NCIT_C91068 isDefinedBy ncit.owl @default.
- NCIT_C91068 label "Hsp90 Inhibitor SNX-5422 Mesylate" @default.
- NCIT_C91068 subClassOf NCIT_C129824 @default.
- NCIT_C91068 subClassOf NCIT_C156880 @default.
- NCIT_C91068 subClassOf NCIT_C1908 @default.
- NCIT_C91068 subClassOf NCIT_C1909 @default.
- NCIT_C91068 subClassOf NCIT_C2189 @default.
- NCIT_C91068 subClassOf NCIT_C274 @default.
- NCIT_C91068 subClassOf NCIT_C74526 @default.
- NCIT_C91068 subClassOf NCIT_C91068 @default.