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- NCIT_C91072 IAO_0000115 "An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Ipatasertib binds to and inhibits the activity of Akt in a non-ATP-competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents." @default.
- NCIT_C91072 NCIT_A32 NCIT_C1909 @default.
- NCIT_C91072 NCIT_A7 NCIT_C41625 @default.
- NCIT_C91072 NCIT_NHC0 "C91072" @default.
- NCIT_C91072 NCIT_P106 "Organic Chemical" @default.
- NCIT_C91072 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C91072 NCIT_P107 "Ipatasertib" @default.
- NCIT_C91072 NCIT_P108 "Ipatasertib" @default.
- NCIT_C91072 NCIT_P207 "C2984014" @default.
- NCIT_C91072 NCIT_P210 "1001264-89-6" @default.
- NCIT_C91072 NCIT_P319 "524Y3IB4HQ" @default.
- NCIT_C91072 NCIT_P322 "CTRP" @default.
- NCIT_C91072 NCIT_P322 "FDA" @default.
- NCIT_C91072 NCIT_P322 "GDC" @default.
- NCIT_C91072 NCIT_P329 "669600" @default.
- NCIT_C91072 NCIT_P330 "669600" @default.
- NCIT_C91072 NCIT_P375 "Ipatasertib" @default.
- NCIT_C91072 NCIT_P399 "669600" @default.
- NCIT_C91072 normalizedInformationContent "100" @default.
- NCIT_C91072 referenceCount "1" @default.
- NCIT_C91072 hasExactSynonym "(2S)-2-(4-chlorophenyl)-1-(4-((5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta(d)pyrimidin-4-yl)piperazin-1-yl(-3-((propan-2-yl)amino)propan-1-one" @default.
- NCIT_C91072 hasExactSynonym "GDC-0068" @default.
- NCIT_C91072 hasExactSynonym "IPATASERTIB" @default.
- NCIT_C91072 hasExactSynonym "Ipatasertib" @default.
- NCIT_C91072 hasExactSynonym "RG-7440" @default.
- NCIT_C91072 inSubset NCIT_C116977 @default.
- NCIT_C91072 inSubset NCIT_C116978 @default.
- NCIT_C91072 inSubset NCIT_C128784 @default.
- NCIT_C91072 inSubset NCIT_C157711 @default.
- NCIT_C91072 inSubset NCIT_C157712 @default.
- NCIT_C91072 inSubset NCIT_C176424 @default.
- NCIT_C91072 inSubset NCIT_C177537 @default.
- NCIT_C91072 inSubset NCIT_C63923 @default.
- NCIT_C91072 type Class @default.
- NCIT_C91072 isDefinedBy ncit.owl @default.
- NCIT_C91072 label "Ipatasertib" @default.
- NCIT_C91072 subClassOf NCIT_C129824 @default.
- NCIT_C91072 subClassOf NCIT_C129825 @default.
- NCIT_C91072 subClassOf NCIT_C1404 @default.
- NCIT_C91072 subClassOf NCIT_C155764 @default.
- NCIT_C91072 subClassOf NCIT_C1742 @default.
- NCIT_C91072 subClassOf NCIT_C1908 @default.
- NCIT_C91072 subClassOf NCIT_C1909 @default.
- NCIT_C91072 subClassOf NCIT_C2189 @default.
- NCIT_C91072 subClassOf NCIT_C274 @default.
- NCIT_C91072 subClassOf NCIT_C471 @default.
- NCIT_C91072 subClassOf NCIT_C61074 @default.
- NCIT_C91072 subClassOf NCIT_C91072 @default.