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- NCIT_C91074 IAO_0000115 "A nanoparticle formulation containing N-glutaryl phosphatidylethanolamine (NGPE)-liposomes encapsulating oxaliplatin and conjugated to the human transferrin (Tf) ligand, with potential antineoplastic activity. Upon infusion of oxaliplatin-encapsulated transferrin-conjugated NGPE liposomes, the transferrin moiety targets and binds to the Tf receptor, which is overexpressed on a variety of human cancer cells. Upon binding and internalization, oxaliplatin is released and its active derivatives alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which results in an inhibition of DNA replication and transcription. By extending the circulation time and specifically targeting transferrin receptors, this formulation may improve the efficacy and safety of oxaliplatin therapy, compared to administration of oxaliplatin alone. NGPE, a reactive phospholipid, is used as a linker to attach the Tf ligand, to the liposome." @default.
- NCIT_C91074 NCIT_A32 NCIT_C1909 @default.
- NCIT_C91074 NCIT_A7 NCIT_C17079 @default.
- NCIT_C91074 NCIT_NHC0 "C91074" @default.
- NCIT_C91074 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C91074 NCIT_P107 "Oxaliplatin-Encapsulated Transferrin-Conjugated N-glutaryl Phosphatidylethanolamine Liposome" @default.
- NCIT_C91074 NCIT_P108 "Oxaliplatin-Encapsulated Transferrin-Conjugated N-glutaryl Phosphatidylethanolamine Liposome" @default.
- NCIT_C91074 NCIT_P208 "CL416281" @default.
- NCIT_C91074 NCIT_P322 "CTRP" @default.
- NCIT_C91074 NCIT_P322 "GDC" @default.
- NCIT_C91074 NCIT_P329 "669661" @default.
- NCIT_C91074 NCIT_P330 "669661" @default.
- NCIT_C91074 NCIT_P375 "Oxaliplatin-Encapsulated Transferrin-Conjugated N-glutaryl Phosphatidylethanolamine Liposome" @default.
- NCIT_C91074 NCIT_P399 "669661" @default.
- NCIT_C91074 normalizedInformationContent "100" @default.
- NCIT_C91074 referenceCount "1" @default.
- NCIT_C91074 hasExactSynonym "MBP-426" @default.
- NCIT_C91074 hasExactSynonym "Oxaliplatin-Encapsulated Tf-Conjugated NGPE-Liposome" @default.
- NCIT_C91074 hasExactSynonym "Oxaliplatin-Encapsulated Transferrin-Conjugated N-glutaryl Phosphatidylethanolamine Liposome" @default.
- NCIT_C91074 inSubset NCIT_C116977 @default.
- NCIT_C91074 inSubset NCIT_C116978 @default.
- NCIT_C91074 inSubset NCIT_C128784 @default.
- NCIT_C91074 inSubset NCIT_C157711 @default.
- NCIT_C91074 inSubset NCIT_C157712 @default.
- NCIT_C91074 inSubset NCIT_C176424 @default.
- NCIT_C91074 inSubset NCIT_C177537 @default.
- NCIT_C91074 type Class @default.
- NCIT_C91074 isDefinedBy ncit.owl @default.
- NCIT_C91074 label "Oxaliplatin-Encapsulated Transferrin-Conjugated N-glutaryl Phosphatidylethanolamine Liposome" @default.
- NCIT_C91074 subClassOf NCIT_C1450 @default.
- NCIT_C91074 subClassOf NCIT_C1590 @default.
- NCIT_C91074 subClassOf NCIT_C186664 @default.
- NCIT_C91074 subClassOf NCIT_C1908 @default.
- NCIT_C91074 subClassOf NCIT_C1909 @default.
- NCIT_C91074 subClassOf NCIT_C2163 @default.
- NCIT_C91074 subClassOf NCIT_C274 @default.
- NCIT_C91074 subClassOf NCIT_C2842 @default.
- NCIT_C91074 subClassOf NCIT_C798 @default.
- NCIT_C91074 subClassOf NCIT_C91074 @default.