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- NCIT_C91076 IAO_0000115 "A cancer vaccine consisting of a recombinant modified vaccinia Ankara (MVA) viral vector encoding the gene for the CD4 epitope-rich C-terminal domain of the Epstein Barr Virus (EBV) antigen EBNA1 and fused to the full-length of the EBV-associated antigen latent membrane protein 2 (LMP2), with potential immunostimulatory and antineoplastic activities. Upon administration, MVA EBNA1/LMP2 vaccine may elicit a cytotoxic T-cell immune response against cancer cells expressing EBNA1 and LMP2. Multi-antigen vaccine therapy may be more efficacious than single-antigen therapy vaccine therapy. EBNA1, a sequence-specific DNA binding protein, plays an important role in EBV episomal genome maintenance and gene transactivation." @default.
- NCIT_C91076 NCIT_NHC0 "C91076" @default.
- NCIT_C91076 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C91076 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C91076 NCIT_P108 "MVA-EBNA1/LMP2 Vaccine" @default.
- NCIT_C91076 NCIT_P208 "CL421473" @default.
- NCIT_C91076 NCIT_P329 "670438" @default.
- NCIT_C91076 NCIT_P330 "670438" @default.
- NCIT_C91076 NCIT_P399 "670438" @default.
- NCIT_C91076 normalizedInformationContent "100" @default.
- NCIT_C91076 referenceCount "1" @default.
- NCIT_C91076 hasExactSynonym "MVA-EBNA1/LMP2 Vaccine" @default.
- NCIT_C91076 inSubset NCIT_C128784 @default.
- NCIT_C91076 inSubset NCIT_C176424 @default.
- NCIT_C91076 type Class @default.
- NCIT_C91076 isDefinedBy ncit.owl @default.
- NCIT_C91076 label "MVA-EBNA1/LMP2 Vaccine" @default.
- NCIT_C91076 subClassOf NCIT_C1572 @default.
- NCIT_C91076 subClassOf NCIT_C1908 @default.
- NCIT_C91076 subClassOf NCIT_C1909 @default.
- NCIT_C91076 subClassOf NCIT_C2313 @default.
- NCIT_C91076 subClassOf NCIT_C307 @default.
- NCIT_C91076 subClassOf NCIT_C308 @default.
- NCIT_C91076 subClassOf NCIT_C91076 @default.
- NCIT_C91076 subClassOf NCIT_C923 @default.
- NCIT_C91076 subClassOf NCIT_C96404 @default.