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- NCIT_C91077 IAO_0000115 "A lipid-based multi-peptide cancer vaccine targeted against multiple cancers with immunopotentiating activity. Therapeutic breast/ovarian/prostate peptide cancer vaccine DPX-0907 is a lyophilized liposomal proprietary preparation comprised of 7 tumor-specific HLA-A2-restricted epitopes (TAAs): Topoisomerase II alpha, B-cell receptor-associated protein 31 (CDM protein), TNF-alpha-converting enzyme (TACE/ADAM17), Abelson homolog 2 (Abl2), gamma catenin (Junction plakoglobin), epithelial discoidin domain receptor 1 (EDDR1) and integrin beta 8 subunit. Upon vaccination, the lyophilized antigen/adjuvant/liposome complex is re-suspended in Montanide 1SA51 VG to create a depot effect, thereby presenting the TAAs to the immune system for a prolonged period of time. This may stimulate a potent cytotoxic T-lymphocyte (CTL) immune response against cancer cells that express these 7 TAAs and share epitopes with the vaccine epitope peptides, resulting in tumor cell lysis. The 7 TAAs are overexpressed on the surface of breast/ovarian and prostate cancer cells and play an important role in tumor cell growth and survival." @default.
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- NCIT_C91077 NCIT_NHC0 "C91077" @default.
- NCIT_C91077 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C91077 NCIT_P107 "Therapeutic Breast/Ovarian/Prostate Peptide Cancer Vaccine DPX-0907" @default.
- NCIT_C91077 NCIT_P108 "Therapeutic Breast/Ovarian/Prostate Peptide Cancer Vaccine DPX-0907" @default.
- NCIT_C91077 NCIT_P207 "C2984018" @default.
- NCIT_C91077 NCIT_P322 "CTRP" @default.
- NCIT_C91077 NCIT_P322 "GDC" @default.
- NCIT_C91077 NCIT_P329 "670456" @default.
- NCIT_C91077 NCIT_P330 "670456" @default.
- NCIT_C91077 NCIT_P375 "Therapeutic Breast/Ovarian/Prostate Peptide Cancer Vaccine DPX-0907" @default.
- NCIT_C91077 NCIT_P399 "670456" @default.
- NCIT_C91077 normalizedInformationContent "100" @default.
- NCIT_C91077 referenceCount "1" @default.
- NCIT_C91077 hasExactSynonym "DPX-0907" @default.
- NCIT_C91077 hasExactSynonym "Therapeutic Breast/Ovarian/Prostate Peptide Cancer Vaccine DPX-0907" @default.
- NCIT_C91077 inSubset NCIT_C116977 @default.
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- NCIT_C91077 type Class @default.
- NCIT_C91077 isDefinedBy ncit.owl @default.
- NCIT_C91077 label "Therapeutic Breast/Ovarian/Prostate Peptide Cancer Vaccine DPX-0907" @default.
- NCIT_C91077 subClassOf NCIT_C129820 @default.
- NCIT_C91077 subClassOf NCIT_C1663 @default.
- NCIT_C91077 subClassOf NCIT_C1908 @default.
- NCIT_C91077 subClassOf NCIT_C1909 @default.
- NCIT_C91077 subClassOf NCIT_C274 @default.
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- NCIT_C91077 subClassOf NCIT_C91077 @default.
- NCIT_C91077 subClassOf NCIT_C923 @default.