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- NCIT_C91078 IAO_0000115 "A chimeric recombinant IgG1 monoclonal antibody directed against human CD20 with potential antineoplastic activity. Ublituximab specifically binds to the B cell-specific cell surface antigen CD20, thereby potentially inducing a B cell-directed complement dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) against CD20-expressing B cells, leading to B cell apoptosis. CD20 is a non-glycosylated cell surface phosphoprotein that is exclusively expressed on B cells during most stages of B cell development and is often overexpressed in B-cell malignancies. Ublituximab has a specific glycosylation profile, with a low fucose content, that may enhance its ADCC response against malignant B cells." @default.
- NCIT_C91078 NCIT_A32 NCIT_C1909 @default.
- NCIT_C91078 NCIT_A7 NCIT_C38896 @default.
- NCIT_C91078 NCIT_NHC0 "C91078" @default.
- NCIT_C91078 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C91078 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C91078 NCIT_P107 "Ublituximab" @default.
- NCIT_C91078 NCIT_P108 "Ublituximab" @default.
- NCIT_C91078 NCIT_P207 "C2934225" @default.
- NCIT_C91078 NCIT_P210 "1174014-05-1" @default.
- NCIT_C91078 NCIT_P319 "U59UGK3IPC" @default.
- NCIT_C91078 NCIT_P322 "CTRP" @default.
- NCIT_C91078 NCIT_P322 "FDA" @default.
- NCIT_C91078 NCIT_P322 "GDC" @default.
- NCIT_C91078 NCIT_P329 "670500" @default.
- NCIT_C91078 NCIT_P330 "670500" @default.
- NCIT_C91078 NCIT_P375 "Ublituximab" @default.
- NCIT_C91078 NCIT_P399 "670500" @default.
- NCIT_C91078 NCIT_R124 NCIT_C17710 @default.
- NCIT_C91078 NCIT_R124 NCIT_C17828 @default.
- NCIT_C91078 NCIT_R124 NCIT_C18219 @default.
- NCIT_C91078 NCIT_R124 NCIT_C19986 @default.
- NCIT_C91078 NCIT_R124 NCIT_C40474 @default.
- NCIT_C91078 normalizedInformationContent "100" @default.
- NCIT_C91078 referenceCount "1" @default.
- NCIT_C91078 hasExactSynonym "LFB-R603" @default.
- NCIT_C91078 hasExactSynonym "TG-1101" @default.
- NCIT_C91078 hasExactSynonym "TG-20" @default.
- NCIT_C91078 hasExactSynonym "TGTX-1101" @default.
- NCIT_C91078 hasExactSynonym "UBLITUXIMAB" @default.
- NCIT_C91078 hasExactSynonym "Ublituximab" @default.
- NCIT_C91078 inSubset NCIT_C116977 @default.
- NCIT_C91078 inSubset NCIT_C116978 @default.
- NCIT_C91078 inSubset NCIT_C128784 @default.
- NCIT_C91078 inSubset NCIT_C157711 @default.
- NCIT_C91078 inSubset NCIT_C157712 @default.
- NCIT_C91078 inSubset NCIT_C176424 @default.
- NCIT_C91078 inSubset NCIT_C177537 @default.
- NCIT_C91078 inSubset NCIT_C63923 @default.
- NCIT_C91078 type Class @default.
- NCIT_C91078 isDefinedBy ncit.owl @default.
- NCIT_C91078 label "Ublituximab" @default.
- NCIT_C91078 subClassOf NCIT_C129821 @default.
- NCIT_C91078 subClassOf NCIT_C129822 @default.
- NCIT_C91078 subClassOf NCIT_C141215 @default.
- NCIT_C91078 subClassOf NCIT_C163758 @default.
- NCIT_C91078 subClassOf NCIT_C164034 @default.
- NCIT_C91078 subClassOf NCIT_C1908 @default.
- NCIT_C91078 subClassOf NCIT_C1909 @default.
- NCIT_C91078 subClassOf NCIT_C20401 @default.
- NCIT_C91078 subClassOf NCIT_C274 @default.
- NCIT_C91078 subClassOf NCIT_C307 @default.
- NCIT_C91078 subClassOf NCIT_C308 @default.
- NCIT_C91078 subClassOf NCIT_C91078 @default.