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- NCIT_C91083 IAO_0000115 "A 0.1% topical formulation of uracil used potentially to lower the incidence of hand-foot syndrome (HFS) (or palmar-plantar erythrodysesthesia) during 5-fluorouracil (5-FU) or 5-FU prodrug capecitabine chemotherapy. Upon local administration of uracil ointment to the skin, uracil competes with capecitabine or 5-FU as substrates for the activating enzyme thymidine phosphorylase and the metabolizing enzyme dihydropyrimidine dehydrogenase. This may prevent the production of 5-FU as well as the breakdown of 5-FU into the toxic metabolites locally. As the 5-FU metabolites are responsible for the presentation of HFS, inhibiting their formation may prevent this adverse effect. By applying a high concentration of uracil locally, the skin toxicities of 5-FU may be countered while preserving the systemic anti-cancer activity of the 5FU." @default.
- NCIT_C91083 NCIT_A32 NCIT_C1909 @default.
- NCIT_C91083 NCIT_NHC0 "C91083" @default.
- NCIT_C91083 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C91083 NCIT_P108 "Uracil Ointment" @default.
- NCIT_C91083 NCIT_P208 "CL416292" @default.
- NCIT_C91083 NCIT_P322 "GDC" @default.
- NCIT_C91083 NCIT_P329 "670894" @default.
- NCIT_C91083 NCIT_P330 "670894" @default.
- NCIT_C91083 NCIT_P375 "Uracil Ointment" @default.
- NCIT_C91083 NCIT_P399 "670894" @default.
- NCIT_C91083 normalizedInformationContent "100" @default.
- NCIT_C91083 referenceCount "1" @default.
- NCIT_C91083 hasExactSynonym "Uracil Ointment" @default.
- NCIT_C91083 inSubset NCIT_C128784 @default.
- NCIT_C91083 inSubset NCIT_C157711 @default.
- NCIT_C91083 inSubset NCIT_C157712 @default.
- NCIT_C91083 inSubset NCIT_C176424 @default.
- NCIT_C91083 inSubset NCIT_C177537 @default.
- NCIT_C91083 type Class @default.
- NCIT_C91083 isDefinedBy ncit.owl @default.
- NCIT_C91083 label "Uracil Ointment" @default.
- NCIT_C91083 subClassOf NCIT_C1908 @default.
- NCIT_C91083 subClassOf NCIT_C1909 @default.
- NCIT_C91083 subClassOf NCIT_C2080 @default.
- NCIT_C91083 subClassOf NCIT_C2459 @default.
- NCIT_C91083 subClassOf NCIT_C26170 @default.
- NCIT_C91083 subClassOf NCIT_C91083 @default.