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- NCIT_C91089 IAO_0000115 "An orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway, thereby inhibiting tumor cell growth. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Dysregulated activation of Hh pathway signaling and uncontrolled cellular proliferation, as is observed in a variety of cancers, may be associated with mutations in the Hh-ligand cell surface receptor Smo." @default.
- NCIT_C91089 NCIT_A32 NCIT_C1909 @default.
- NCIT_C91089 NCIT_A7 NCIT_C29980 @default.
- NCIT_C91089 NCIT_NHC0 "C91089" @default.
- NCIT_C91089 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C91089 NCIT_P107 "Smoothened Antagonist LEQ506" @default.
- NCIT_C91089 NCIT_P108 "Smoothened Antagonist LEQ506" @default.
- NCIT_C91089 NCIT_P208 "CL421477" @default.
- NCIT_C91089 NCIT_P210 "1204975-42-7" @default.
- NCIT_C91089 NCIT_P319 "6SJX1T5HJD" @default.
- NCIT_C91089 NCIT_P322 "CTRP" @default.
- NCIT_C91089 NCIT_P322 "FDA" @default.
- NCIT_C91089 NCIT_P322 "GDC" @default.
- NCIT_C91089 NCIT_P329 "671850" @default.
- NCIT_C91089 NCIT_P330 "671850" @default.
- NCIT_C91089 NCIT_P375 "Smoothened Antagonist LEQ506" @default.
- NCIT_C91089 NCIT_P399 "671850" @default.
- NCIT_C91089 normalizedInformationContent "100" @default.
- NCIT_C91089 referenceCount "1" @default.
- NCIT_C91089 hasExactSynonym "LEQ506" @default.
- NCIT_C91089 hasExactSynonym "NVP-LEQ-506" @default.
- NCIT_C91089 hasExactSynonym "Smoothened Antagonist LEQ506" @default.
- NCIT_C91089 inSubset NCIT_C116977 @default.
- NCIT_C91089 inSubset NCIT_C116978 @default.
- NCIT_C91089 inSubset NCIT_C128784 @default.
- NCIT_C91089 inSubset NCIT_C157711 @default.
- NCIT_C91089 inSubset NCIT_C157712 @default.
- NCIT_C91089 inSubset NCIT_C176424 @default.
- NCIT_C91089 inSubset NCIT_C177537 @default.
- NCIT_C91089 inSubset NCIT_C63923 @default.
- NCIT_C91089 type Class @default.
- NCIT_C91089 isDefinedBy ncit.owl @default.
- NCIT_C91089 label "Smoothened Antagonist LEQ506" @default.
- NCIT_C91089 subClassOf NCIT_C155725 @default.
- NCIT_C91089 subClassOf NCIT_C163758 @default.
- NCIT_C91089 subClassOf NCIT_C188731 @default.
- NCIT_C91089 subClassOf NCIT_C1908 @default.
- NCIT_C91089 subClassOf NCIT_C1909 @default.
- NCIT_C91089 subClassOf NCIT_C2189 @default.
- NCIT_C91089 subClassOf NCIT_C274 @default.
- NCIT_C91089 subClassOf NCIT_C91089 @default.