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- NCIT_C91100 IAO_0000115 "An orally bioavailable, small molecule inhibitor of vascular endothelial growth factor (VEGF) synthesis with potential antiangiogenesis and antineoplastic activities. Emvododstat targets post-transcriptionally by selectively binding the 5'- and 3'-untranslated regions (UTR) of VEGF messenger RNA (mRNA), thereby preventing translation of VEGF. This inhibits VEGF protein production and decreases its levels in the tumor and bloodstream. In turn, this may result in the inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and eventually the induction of tumor cell death. VEGFs are upregulated in a variety of tumor cell types and play key roles during angiogenesis. In addition, emvododstat may enhance the antitumor activity of other chemotherapeutic agents." @default.
- NCIT_C91100 NCIT_A32 NCIT_C1909 @default.
- NCIT_C91100 NCIT_NHC0 "C91100" @default.
- NCIT_C91100 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C91100 NCIT_P107 "Emvododstat" @default.
- NCIT_C91100 NCIT_P108 "Emvododstat" @default.
- NCIT_C91100 NCIT_P207 "C2984037" @default.
- NCIT_C91100 NCIT_P210 "1256565-36-2" @default.
- NCIT_C91100 NCIT_P319 "053QD2I96A" @default.
- NCIT_C91100 NCIT_P322 "CTRP" @default.
- NCIT_C91100 NCIT_P322 "FDA" @default.
- NCIT_C91100 NCIT_P322 "GDC" @default.
- NCIT_C91100 NCIT_P329 "564407" @default.
- NCIT_C91100 NCIT_P330 "564407" @default.
- NCIT_C91100 NCIT_P375 "VEGF Inhibitor PTC299" @default.
- NCIT_C91100 NCIT_P399 "564407" @default.
- NCIT_C91100 normalizedInformationContent "100" @default.
- NCIT_C91100 referenceCount "1" @default.
- NCIT_C91100 hasExactSynonym "EMVODODSTAT" @default.
- NCIT_C91100 hasExactSynonym "Emvododstat" @default.
- NCIT_C91100 hasExactSynonym "PTC299" @default.
- NCIT_C91100 inSubset NCIT_C116977 @default.
- NCIT_C91100 inSubset NCIT_C116978 @default.
- NCIT_C91100 inSubset NCIT_C128784 @default.
- NCIT_C91100 inSubset NCIT_C157711 @default.
- NCIT_C91100 inSubset NCIT_C157712 @default.
- NCIT_C91100 inSubset NCIT_C173381 @default.
- NCIT_C91100 inSubset NCIT_C173383 @default.
- NCIT_C91100 inSubset NCIT_C176424 @default.
- NCIT_C91100 inSubset NCIT_C177537 @default.
- NCIT_C91100 inSubset NCIT_C63923 @default.
- NCIT_C91100 type Class @default.
- NCIT_C91100 isDefinedBy ncit.owl @default.
- NCIT_C91100 label "Emvododstat" @default.
- NCIT_C91100 subClassOf NCIT_C1404 @default.
- NCIT_C91100 subClassOf NCIT_C163758 @default.
- NCIT_C91100 subClassOf NCIT_C163953 @default.
- NCIT_C91100 subClassOf NCIT_C1742 @default.
- NCIT_C91100 subClassOf NCIT_C1908 @default.
- NCIT_C91100 subClassOf NCIT_C1909 @default.
- NCIT_C91100 subClassOf NCIT_C1967 @default.
- NCIT_C91100 subClassOf NCIT_C274 @default.
- NCIT_C91100 subClassOf NCIT_C471 @default.
- NCIT_C91100 subClassOf NCIT_C91100 @default.
- NCIT_C91100 subClassOf NCIT_C93259 @default.