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- NCIT_C91302 NCIT_NHC0 "C91302" @default.
- NCIT_C91302 NCIT_P106 "Functional Concept" @default.
- NCIT_C91302 NCIT_P108 "Small Leucine-Rich Proteoglycan (SLRP) Pathway" @default.
- NCIT_C91302 NCIT_P207 "C2984143" @default.
- NCIT_C91302 NCIT_P216 "h_slrpPathway" @default.
- NCIT_C91302 NCIT_P325 "The small leucine-rich proteoglycans (SLRPs) are a family of proteins that are present in extracellular matrix and that share in common multiple repeats of a leucine-rich structural motif, flanked by cysteine residues. These proteins appear to interact in many cases with collagen, modifying the deposition and arrangement of collagen fibers in the extracellular matrix, and also with cells and with soluble growth factors. The interaction of SLRPs with cells and with growth factors like TGF-beta may affect the proliferation of cells in addition to modifying the extracellular environment. Post-translational modification of SLRPs with carbohydrates and sulfate-containing groups appears to modify the function of SLRPs. Changes in SLRP expression and modification in cornea, atherosclerotic plaque, joints, bone, tendons, and kidney may be associated with disease progression in those tissues. Decorin is one SLRP expressed throughout the body that stabilizes collagen fibrils and that also antagonizes the action of the cytokine TGF-beta, blocking cell cycle progression, and potentially playing a role in cancer and wound healing. The SLRP biglycan is expressed in bone and other connective tissues and genetic disruption of biglycan in mice causes low bone mass similar to osteoporosis. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C91302 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C91302 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C91302 referenceCount "3" @default.
- NCIT_C91302 hasExactSynonym "Small Leucine-Rich Proteoglycan (SLRP) Molecules" @default.
- NCIT_C91302 hasExactSynonym "Small Leucine-Rich Proteoglycan (SLRP) Pathway" @default.
- NCIT_C91302 type Class @default.
- NCIT_C91302 isDefinedBy ncit.owl @default.
- NCIT_C91302 label "Small Leucine-Rich Proteoglycan (SLRP) Pathway" @default.
- NCIT_C91302 subClassOf NCIT_C20633 @default.
- NCIT_C91302 subClassOf NCIT_C39704 @default.
- NCIT_C91302 subClassOf NCIT_C91302 @default.