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- NCIT_C91310 NCIT_NHC0 "C91310" @default.
- NCIT_C91310 NCIT_P106 "Functional Concept" @default.
- NCIT_C91310 NCIT_P108 "B Lymphocyte Cell Surface Molecule Pathway" @default.
- NCIT_C91310 NCIT_P207 "C2984151" @default.
- NCIT_C91310 NCIT_P216 "h_blymphocytePathway" @default.
- NCIT_C91310 NCIT_P325 "B cells must communicate with their environment to participate in the immune system as the source of antigen-specific immunoglobulins. Cell surface proteins on B cells receive signals from the exterior, adhere to other cells, and transmit signals to other cells. Antigen recognized by a B cell's immunoglobulin is presented in MHC Class II to T cells during B cell activation. Cell surface immunoglobulins are a key to B cell function, assisting in the response of B cells to specific antigen recognized by that cell's immunoglobulin. CD54 (ICAM-1) is an adhesion molecule involved in the binding of B cells to other cell types and LFA-1 is an integrin adhesion protein with two subunits that binds to ICAM. CD35 and CD21 are receptors for complement factors that stimulate the B cell response when complement is activated. CD80 and CD40 bind to T cell proteins (CD28 and CD40L, respectively) to provide costimulatory signals in the B cell-T cell interaction required for B cell activation. CD45 is a protein tyrosine phosphatase that regulates activation of B cells and T cells through dephosphorylation of signaling factors. CD32 is a receptor for IgG Fc, and is also called Fc gamma RII. The number of proteins on the surface of B cell proteins indicates the complexity of regulation of B cell activation. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C91310 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C91310 normalizedInformationContent "89.350088392419622" @default.
- NCIT_C91310 referenceCount "5" @default.
- NCIT_C91310 hasExactSynonym "B Lymphocyte Cell Surface Molecule Pathway" @default.
- NCIT_C91310 hasExactSynonym "B Lymphocyte Cell Surface Molecules" @default.
- NCIT_C91310 type Class @default.
- NCIT_C91310 isDefinedBy ncit.owl @default.
- NCIT_C91310 label "B Lymphocyte Cell Surface Molecule Pathway" @default.
- NCIT_C91310 subClassOf NCIT_C19779 @default.
- NCIT_C91310 subClassOf NCIT_C20633 @default.
- NCIT_C91310 subClassOf NCIT_C39698 @default.
- NCIT_C91310 subClassOf NCIT_C91310 @default.