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- NCIT_C91320 NCIT_NHC0 "C91320" @default.
- NCIT_C91320 NCIT_P106 "Functional Concept" @default.
- NCIT_C91320 NCIT_P108 "Biosynthesis of Glycine and Serine Pathway" @default.
- NCIT_C91320 NCIT_P207 "C2984161" @default.
- NCIT_C91320 NCIT_P216 "GlycinePathway" @default.
- NCIT_C91320 NCIT_P325 "Intermediates in energy production pathways such as glycolysis and the Kreb's cycle are commonly the starting point for the biosynthesis of amino acids. The glycolytic intermediate 3-phosphoglycerate is the starting point for the biosynthesis of serine and glycine. First, 3-phosphoglycerate is oxidized and then transaminated to produce 3-phosphoserine. Phosphoserine hydrolase hydrolyzes the phosphate in 3-phosphoserine to produce serine. The side chain carbon of serine is removed to create glycine, which has only hydrogen as its side chain. The removal of the serine side chain is accomplished by transferring the carbon to tetrahydrofolate, a carrier of one-carbon groups. Genetic deficiency of the first enzyme in the pathway, 3-phosphoglycerate dehydrogenase, leads to impaired myelination of neurons and impaired development of the central nervous system. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C91320 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C91320 normalizedInformationContent "100" @default.
- NCIT_C91320 referenceCount "1" @default.
- NCIT_C91320 hasExactSynonym "Biosynthesis of Glycine and Serine Pathway" @default.
- NCIT_C91320 hasExactSynonym "Biosynthesis of Glycine and Serine" @default.
- NCIT_C91320 type Class @default.
- NCIT_C91320 isDefinedBy ncit.owl @default.
- NCIT_C91320 label "Biosynthesis of Glycine and Serine Pathway" @default.
- NCIT_C91320 subClassOf NCIT_C18611 @default.
- NCIT_C91320 subClassOf NCIT_C20633 @default.
- NCIT_C91320 subClassOf NCIT_C39730 @default.
- NCIT_C91320 subClassOf NCIT_C91320 @default.