Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C91321> ?p ?o ?g. }
Showing items 1 to 17 of
17
with 100 items per page.
- NCIT_C91321 NCIT_NHC0 "C91321" @default.
- NCIT_C91321 NCIT_P106 "Functional Concept" @default.
- NCIT_C91321 NCIT_P108 "Catabolic Pathway for Asparagine and Aspartate" @default.
- NCIT_C91321 NCIT_P207 "C2984162" @default.
- NCIT_C91321 NCIT_P216 "asparaginepathway" @default.
- NCIT_C91321 NCIT_P325 "Aspartate and asparagine are catabolized into oxaloacetate and the Kreb's cycle in a fairly direct pathway for amino acids with four carbons. The first step for asparagine catabolism is hydrolysis by the enzyme asparaginase, releasing aspartate and ammonia. Aspartate is then transaminated by aspartate transaminase to exchange its amino group onto alpha-ketoglutarate and be converted into oxaloacetate. As part of the Kreb's cycle, the carbon skeleton of oxaloacetate can generate energy and provide material for biosynthesis. The enzyme asparaginase is used as a cancer treatment through injection. Some cancers such as leukemias are highly dependent on asparagine circulating in the blood that comes from the diet. The required asparagine helps to support the rapid growth of malignant cells. Injection of asparaginase metabolizes the asparagine in the blood, withdrawing the supply of this essential nutrient from tumor cells, and causing asparagine-dependent tumor cells to die. Normal cells provide enough asparagine for their own needs through biosynthesis and are affected to a lesser extent by this treatment. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C91321 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C91321 normalizedInformationContent "100" @default.
- NCIT_C91321 referenceCount "1" @default.
- NCIT_C91321 hasExactSynonym "Catabolic Pathway for Asparagine and Aspartate" @default.
- NCIT_C91321 type Class @default.
- NCIT_C91321 isDefinedBy ncit.owl @default.
- NCIT_C91321 label "Catabolic Pathway for Asparagine and Aspartate" @default.
- NCIT_C91321 subClassOf NCIT_C18611 @default.
- NCIT_C91321 subClassOf NCIT_C20633 @default.
- NCIT_C91321 subClassOf NCIT_C39730 @default.
- NCIT_C91321 subClassOf NCIT_C91321 @default.