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- NCIT_C91326 NCIT_NHC0 "C91326" @default.
- NCIT_C91326 NCIT_P106 "Functional Concept" @default.
- NCIT_C91326 NCIT_P108 "Lactose Synthesis Pathway" @default.
- NCIT_C91326 NCIT_P208 "CL422154" @default.
- NCIT_C91326 NCIT_P216 "LactosePathway" @default.
- NCIT_C91326 NCIT_P325 "The synthesis of glycosidic bonds between monosaccharides requires energy input, energy that is provided by joining sugar monomers to a nucleotide such as UDP. Glycosyltransferases join two sugar monomers together, with UDP as the leaving group that drives the reaction forward. One glycosyltransferases is galactosyltransferase. Galactosyltransferase catalyzes the formation of a glycosidic bond between galactose and N-acetyl-D-glucosamine to create N-acetyllactosamine (D-galactosyl-N-acetyl-D-glucosamine), found in the oligosaccharides of glycoproteins. Galactosyltransferase is broadly expressed. This enzyme also catalyzes the synthesis of the disaccharide lactose, the sugar found in milk. Although this enzyme is broadly expressed, lactose production only occurs in mammary glands. Lactose production is restricted to the mammary glands because galactosyltransferase alone does not have the substrate specificity required to produce lactose. The complete lactose synthase complex includes galactosyltransferase and another non-catalytic subunit, alpha-lactalbumin. In the presence of alpha-lactalbumin, galactosyltransferase substrate specificity is switched to use glucose, resulting in lactose production rather than N-acetyllactosamine. The folding of alpha-lactalbumin, which is related to lysozyme, has been studied extensively as a model of the mechanisms involved in protein folding. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C91326 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C91326 normalizedInformationContent "100" @default.
- NCIT_C91326 referenceCount "1" @default.
- NCIT_C91326 hasExactSynonym "Lactose Synthesis Pathway" @default.
- NCIT_C91326 hasExactSynonym "Lactose Synthesis" @default.
- NCIT_C91326 type Class @default.
- NCIT_C91326 isDefinedBy ncit.owl @default.
- NCIT_C91326 label "Lactose Synthesis Pathway" @default.
- NCIT_C91326 subClassOf NCIT_C18611 @default.
- NCIT_C91326 subClassOf NCIT_C20633 @default.
- NCIT_C91326 subClassOf NCIT_C39726 @default.
- NCIT_C91326 subClassOf NCIT_C91326 @default.