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- NCIT_C91330 NCIT_NHC0 "C91330" @default.
- NCIT_C91330 NCIT_P106 "Functional Concept" @default.
- NCIT_C91330 NCIT_P108 "Feeding Amino Groups into the Urea Cycle" @default.
- NCIT_C91330 NCIT_P207 "C2984169" @default.
- NCIT_C91330 NCIT_P216 "ureacyclePathway" @default.
- NCIT_C91330 NCIT_P325 "Excess amino acids in the body can be used as a source of energy, with their carbon skeleton converted to metabolic intermediates such as acetyl-CoA or intermediates in the Krebs cycle. The metabolic breakdown of amino acids releases nitrogen that must be converted to a relatively non-toxic form and then excreted. In mammals, the nitrogen is converted to urea in the liver through a series of reactions called the urea cycle. The ammonia released through the deamination of amino acids is reacted to produce carbamoyl phosphate, a reaction catalyzed by carbamoyl phosphate synthase. The enzyme ornithine transcarbamoylase is found in mitochondria and converts ornithine into citrulline. Citrulline is exported into the cytoplasm where another nitrogen for urea is acquired from aspartate, followed by the release of fumarate to form the amino acid arginine. Urea is released from arginine by the enzyme arginase, bringing the cycle back around to ornithine. The general route of entry for amino acids into the urea cycle is through transamination, the transfer of their amino group to alpha-ketoglutarate to form glutamate. The amino group from glutamate is released by glutamate dehydrogenase to create an ammonium ion. The ammonium ion is used to make carbamoyl phosphate, and ultimately urea through the urea cycle. Different amino acids can enter this pathway by different routes. The transfer of the amino group from aspartate to alpha-ketobutyrate creates oxaloacetate, a Krebs cycle intermediate. Alanine goes through transamination to release pyruvate, which can be used as fuel. Genetic defects that completely block the urea cycle are not observed in people, perhaps since such a defect would be fatal. Mutations that reduce the activity of the urea cycle have been observed, with serious affects on mental functioning and other toxicities caused by elevated levels of ammonia. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C91330 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C91330 normalizedInformationContent "100" @default.
- NCIT_C91330 referenceCount "1" @default.
- NCIT_C91330 hasExactSynonym "Feeding Amino Groups into the Urea Cycle" @default.
- NCIT_C91330 hasExactSynonym "The reactions that feed amino groups into the urea cycle" @default.
- NCIT_C91330 type Class @default.
- NCIT_C91330 isDefinedBy ncit.owl @default.
- NCIT_C91330 label "Feeding Amino Groups into the Urea Cycle" @default.
- NCIT_C91330 subClassOf NCIT_C18611 @default.
- NCIT_C91330 subClassOf NCIT_C20633 @default.
- NCIT_C91330 subClassOf NCIT_C39727 @default.
- NCIT_C91330 subClassOf NCIT_C91330 @default.