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- NCIT_C91387 IAO_0000115 "An inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemo- and/or radiosensitizing activity. PARP inhibitor E7016 selectively binds to PARP and prevents PARP mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks and promotes genomic instability and eventually leads to apoptosis. In addition, this agent may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks." @default.
- NCIT_C91387 NCIT_A32 NCIT_C1909 @default.
- NCIT_C91387 NCIT_A7 NCIT_C104720 @default.
- NCIT_C91387 NCIT_A7 NCIT_C48215 @default.
- NCIT_C91387 NCIT_NHC0 "C91387" @default.
- NCIT_C91387 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C91387 NCIT_P107 "PARP Inhibitor E7016" @default.
- NCIT_C91387 NCIT_P108 "PARP Inhibitor E7016" @default.
- NCIT_C91387 NCIT_P208 "CL421589" @default.
- NCIT_C91387 NCIT_P210 "902128-92-1" @default.
- NCIT_C91387 NCIT_P319 "M8926C7ILX" @default.
- NCIT_C91387 NCIT_P322 "CTRP" @default.
- NCIT_C91387 NCIT_P322 "FDA" @default.
- NCIT_C91387 NCIT_P322 "GDC" @default.
- NCIT_C91387 NCIT_P329 "674406" @default.
- NCIT_C91387 NCIT_P330 "674406" @default.
- NCIT_C91387 NCIT_P375 "PARP Inhibitor E7016" @default.
- NCIT_C91387 NCIT_P399 "674406" @default.
- NCIT_C91387 NCIT_R146 NCIT_C104101 @default.
- NCIT_C91387 NCIT_R146 NCIT_C16554 @default.
- NCIT_C91387 NCIT_R146 NCIT_C17021 @default.
- NCIT_C91387 NCIT_R146 NCIT_C17210 @default.
- NCIT_C91387 NCIT_R146 NCIT_C17434 @default.
- NCIT_C91387 NCIT_R146 NCIT_C20027 @default.
- NCIT_C91387 NCIT_R146 NCIT_C21170 @default.
- NCIT_C91387 NCIT_R146 NCIT_C26548 @default.
- NCIT_C91387 NCIT_R146 NCIT_C48215 @default.
- NCIT_C91387 normalizedInformationContent "100" @default.
- NCIT_C91387 referenceCount "1" @default.
- NCIT_C91387 hasExactSynonym "E-7016" @default.
- NCIT_C91387 hasExactSynonym "E7016" @default.
- NCIT_C91387 hasExactSynonym "PARP Inhibitor E7016" @default.
- NCIT_C91387 inSubset NCIT_C116977 @default.
- NCIT_C91387 inSubset NCIT_C116978 @default.
- NCIT_C91387 inSubset NCIT_C128784 @default.
- NCIT_C91387 inSubset NCIT_C157711 @default.
- NCIT_C91387 inSubset NCIT_C157712 @default.
- NCIT_C91387 inSubset NCIT_C176424 @default.
- NCIT_C91387 inSubset NCIT_C177537 @default.
- NCIT_C91387 inSubset NCIT_C63923 @default.
- NCIT_C91387 type Class @default.
- NCIT_C91387 isDefinedBy ncit.owl @default.
- NCIT_C91387 label "PARP Inhibitor E7016" @default.
- NCIT_C91387 subClassOf NCIT_C163758 @default.
- NCIT_C91387 subClassOf NCIT_C1908 @default.
- NCIT_C91387 subClassOf NCIT_C1909 @default.
- NCIT_C91387 subClassOf NCIT_C274 @default.
- NCIT_C91387 subClassOf NCIT_C471 @default.
- NCIT_C91387 subClassOf NCIT_C62554 @default.
- NCIT_C91387 subClassOf NCIT_C91387 @default.