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- NCIT_C91388 IAO_0000115 "An orally bioavailable proteasome inhibitor with potential antineoplastic activity. Proteasome inhibitor ONX 0912 inhibits the activity of the proteasome, thereby blocking the targeted proteolysis normally performed by the proteasome; this may result in an accumulation of unwanted or misfolded proteins. Disruption of various cell signaling pathways may follow, eventually leading to the induction of apoptosis and inhibition of tumor growth. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquitinated." @default.
- NCIT_C91388 NCIT_A32 NCIT_C1909 @default.
- NCIT_C91388 NCIT_A7 NCIT_C13737 @default.
- NCIT_C91388 NCIT_NHC0 "C91388" @default.
- NCIT_C91388 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C91388 NCIT_P107 "Oprozomib" @default.
- NCIT_C91388 NCIT_P108 "Oprozomib" @default.
- NCIT_C91388 NCIT_P207 "C2976183" @default.
- NCIT_C91388 NCIT_P210 "935888-69-0" @default.
- NCIT_C91388 NCIT_P319 "MZ37792Y8J" @default.
- NCIT_C91388 NCIT_P322 "CTRP" @default.
- NCIT_C91388 NCIT_P322 "FDA" @default.
- NCIT_C91388 NCIT_P322 "GDC" @default.
- NCIT_C91388 NCIT_P329 "674605" @default.
- NCIT_C91388 NCIT_P330 "674605" @default.
- NCIT_C91388 NCIT_P350 "C25H32N4O7S" @default.
- NCIT_C91388 NCIT_P375 "Oprozomib" @default.
- NCIT_C91388 NCIT_P399 "674605" @default.
- NCIT_C91388 normalizedInformationContent "100" @default.
- NCIT_C91388 referenceCount "1" @default.
- NCIT_C91388 hasExactSynonym "O-methyl-N-((2-methylthiazol-5-yl)carbonyl)-l-seryl-O-methyl-N-((1S)-1-benzyl-2-((2R)-2-methyloxiran-2-yl)-2-oxoethyl)-l-serinamide" @default.
- NCIT_C91388 hasExactSynonym "ONX 0912" @default.
- NCIT_C91388 hasExactSynonym "OPROZOMIB" @default.
- NCIT_C91388 hasExactSynonym "Oprozomib" @default.
- NCIT_C91388 hasExactSynonym "PR-047" @default.
- NCIT_C91388 hasExactSynonym "Proteasome Inhibitor ONX 0912" @default.
- NCIT_C91388 inSubset NCIT_C116977 @default.
- NCIT_C91388 inSubset NCIT_C116978 @default.
- NCIT_C91388 inSubset NCIT_C128784 @default.
- NCIT_C91388 inSubset NCIT_C157711 @default.
- NCIT_C91388 inSubset NCIT_C157712 @default.
- NCIT_C91388 inSubset NCIT_C176424 @default.
- NCIT_C91388 inSubset NCIT_C177537 @default.
- NCIT_C91388 inSubset NCIT_C63923 @default.
- NCIT_C91388 type Class @default.
- NCIT_C91388 isDefinedBy ncit.owl @default.
- NCIT_C91388 label "Oprozomib" @default.
- NCIT_C91388 subClassOf NCIT_C163758 @default.
- NCIT_C91388 subClassOf NCIT_C1908 @default.
- NCIT_C91388 subClassOf NCIT_C1909 @default.
- NCIT_C91388 subClassOf NCIT_C2160 @default.
- NCIT_C91388 subClassOf NCIT_C274 @default.
- NCIT_C91388 subClassOf NCIT_C471 @default.
- NCIT_C91388 subClassOf NCIT_C91388 @default.