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- NCIT_C91409 IAO_0000115 "The hydrochloride salt of a guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation." @default.
- NCIT_C91409 NCIT_A32 NCIT_C1909 @default.
- NCIT_C91409 NCIT_A6 NCIT_C661 @default.
- NCIT_C91409 NCIT_NHC0 "C91409" @default.
- NCIT_C91409 NCIT_P106 "Organic Chemical" @default.
- NCIT_C91409 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C91409 NCIT_P108 "Mitoguazone Dihydrochloride" @default.
- NCIT_C91409 NCIT_P175 "32946" @default.
- NCIT_C91409 NCIT_P207 "C0771772" @default.
- NCIT_C91409 NCIT_P210 "7059-23-6" @default.
- NCIT_C91409 NCIT_P319 "NNI098FX5Q" @default.
- NCIT_C91409 NCIT_P322 "FDA" @default.
- NCIT_C91409 NCIT_P322 "GDC" @default.
- NCIT_C91409 NCIT_P325 "A substance being studied in the treatment of some leukemias and lymphomas. It blocks the growth of cells and may cause cancer cells to die. It is a type of polyamine synthesis inhibitor." @default.
- NCIT_C91409 NCIT_P350 "C5H12N8.2HCl" @default.
- NCIT_C91409 NCIT_P375 "Mitoguazone Dihydrochloride" @default.
- NCIT_C91409 normalizedInformationContent "100" @default.
- NCIT_C91409 referenceCount "1" @default.
- NCIT_C91409 hasExactSynonym "1,1'-((Methylethanediylidene)Dinitrilo)Diguanidine Dihydrochloride" @default.
- NCIT_C91409 hasExactSynonym "2,2'-(1-Methyl-1,2-Ethanediylidene)Bis(Hydrazinecarboximidamide) Dihydrochloride" @default.
- NCIT_C91409 hasExactSynonym "MGBG 2HCl" @default.
- NCIT_C91409 hasExactSynonym "MITOGUAZONE DIHYDROCHLORIDE" @default.
- NCIT_C91409 hasExactSynonym "Methylglyoxal Bis(amidinohydrazone) Dihydrochloride" @default.
- NCIT_C91409 hasExactSynonym "Mitoguazone Dihydrochloride" @default.
- NCIT_C91409 hasExactSynonym "Pyruvaldehyde Bis(amidinohydrazone) Hydrochloride" @default.
- NCIT_C91409 hasExactSynonym "mitoguazone dihydrochloride" @default.
- NCIT_C91409 inSubset NCIT_C128784 @default.
- NCIT_C91409 inSubset NCIT_C157711 @default.
- NCIT_C91409 inSubset NCIT_C157712 @default.
- NCIT_C91409 inSubset NCIT_C177537 @default.
- NCIT_C91409 inSubset NCIT_C63923 @default.
- NCIT_C91409 type Class @default.
- NCIT_C91409 isDefinedBy ncit.owl @default.
- NCIT_C91409 label "Mitoguazone Dihydrochloride" @default.
- NCIT_C91409 subClassOf NCIT_C129824 @default.
- NCIT_C91409 subClassOf NCIT_C1908 @default.
- NCIT_C91409 subClassOf NCIT_C1909 @default.
- NCIT_C91409 subClassOf NCIT_C2076 @default.
- NCIT_C91409 subClassOf NCIT_C2090 @default.
- NCIT_C91409 subClassOf NCIT_C2189 @default.
- NCIT_C91409 subClassOf NCIT_C274 @default.
- NCIT_C91409 subClassOf NCIT_C471 @default.
- NCIT_C91409 subClassOf NCIT_C91409 @default.