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- NCIT_C91439 NCIT_NHC0 "C91439" @default.
- NCIT_C91439 NCIT_P106 "Functional Concept" @default.
- NCIT_C91439 NCIT_P108 "Leukocyte Transendothelial Migration Pathway" @default.
- NCIT_C91439 NCIT_P207 "C2984252" @default.
- NCIT_C91439 NCIT_P215 "hsa04670" @default.
- NCIT_C91439 NCIT_P325 "Leukocyte migration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (CAM) and then migrate across the vascular endothelium. A leukocyte adherent to CAMs on the endothelial cells moves forward by leading-edge protrusion and retraction of its tail. In this process, alphaL/beta2 integrin activates through Vav1, RhoA, which subsequently activates the kinase p160ROCK. ROCK activation leads to MLC phosphorylation, resulting in retraction of the actin cytoskeleton. Moreover, leukocytes activate endothelial cell signals that stimulate endothelial cell retraction during localized dissociation of the endothelial cell junctions. ICAM-1-mediated signals activate an endothelial cell calcium flux and PKC, which are required for ICAM-1 dependent leukocyte migration. VCAM-1 is involved in the opening of the "endothelial passage" through which leukocytes can extravasate. In this regard, VCAM-1 ligation induces NADPH oxidase activation and the production of reactive oxygen species (ROS) in a Rac-mediated manner, with subsequent activation of matrix metalloproteinases and loss of VE-cadherin-mediated adhesion." @default.
- NCIT_C91439 normalizedInformationContent "67.068145939794377" @default.
- NCIT_C91439 referenceCount "145" @default.
- NCIT_C91439 hasExactSynonym "Leukocyte Transendothelial Migration Pathway" @default.
- NCIT_C91439 hasExactSynonym "Leukocyte transendothelial migration" @default.
- NCIT_C91439 type Class @default.
- NCIT_C91439 isDefinedBy ncit.owl @default.
- NCIT_C91439 label "Leukocyte Transendothelial Migration Pathway" @default.
- NCIT_C91439 subClassOf NCIT_C19779 @default.
- NCIT_C91439 subClassOf NCIT_C20633 @default.
- NCIT_C91439 subClassOf NCIT_C39698 @default.
- NCIT_C91439 subClassOf NCIT_C91439 @default.