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- NCIT_C91443 NCIT_NHC0 "C91443" @default.
- NCIT_C91443 NCIT_P106 "Functional Concept" @default.
- NCIT_C91443 NCIT_P108 "Neurotrophin Signaling Pathway" @default.
- NCIT_C91443 NCIT_P207 "C2984256" @default.
- NCIT_C91443 NCIT_P215 "hsa04722" @default.
- NCIT_C91443 NCIT_P325 "Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and negative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory." @default.
- NCIT_C91443 normalizedInformationContent "65.349614538394277" @default.
- NCIT_C91443 referenceCount "188" @default.
- NCIT_C91443 hasExactSynonym "Neurotrophin Signaling Pathway" @default.
- NCIT_C91443 hasExactSynonym "Neurotrophin signaling pathway" @default.
- NCIT_C91443 type Class @default.
- NCIT_C91443 isDefinedBy ncit.owl @default.
- NCIT_C91443 label "Neurotrophin Signaling Pathway" @default.
- NCIT_C91443 subClassOf NCIT_C20633 @default.
- NCIT_C91443 subClassOf NCIT_C39704 @default.
- NCIT_C91443 subClassOf NCIT_C91443 @default.