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- NCIT_C91444 NCIT_NHC0 "C91444" @default.
- NCIT_C91444 NCIT_P106 "Functional Concept" @default.
- NCIT_C91444 NCIT_P108 "Non-Homologous End-Joining Pathway" @default.
- NCIT_C91444 NCIT_P207 "C2984257" @default.
- NCIT_C91444 NCIT_P215 "hsa03450" @default.
- NCIT_C91444 NCIT_P325 "Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone." @default.
- NCIT_C91444 normalizedInformationContent "79.853901415798049" @default.
- NCIT_C91444 referenceCount "21" @default.
- NCIT_C91444 hasExactSynonym "NHEJ Pathway" @default.
- NCIT_C91444 hasExactSynonym "Non-Homologous End-Joining Pathway" @default.
- NCIT_C91444 hasExactSynonym "Non-homologous end-joining" @default.
- NCIT_C91444 type Class @default.
- NCIT_C91444 isDefinedBy ncit.owl @default.
- NCIT_C91444 label "Non-Homologous End-Joining Pathway" @default.
- NCIT_C91444 subClassOf NCIT_C20633 @default.
- NCIT_C91444 subClassOf NCIT_C39705 @default.
- NCIT_C91444 subClassOf NCIT_C91444 @default.