Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C91445> ?p ?o ?g. }
Showing items 1 to 18 of
18
with 100 items per page.
- NCIT_C91445 NCIT_NHC0 "C91445" @default.
- NCIT_C91445 NCIT_P106 "Functional Concept" @default.
- NCIT_C91445 NCIT_P108 "Non-Small Cell Lung Cancer Pathway" @default.
- NCIT_C91445 NCIT_P207 "C2984258" @default.
- NCIT_C91445 NCIT_P215 "hsa05223" @default.
- NCIT_C91445 NCIT_P325 "Non-small-cell lung cancer (NSCLC) accounts for approximately 80% of lung cancer and represents a heterogeneous group of cancers, consisting mainly of squamous cell (SCC), adeno (AC) and large-cell carcinoma. Molecular mechanisms altered in NSCLC include activation of oncogenes, such as K-RAS and c-erbB-2, and inactivation of tumor suppressor genes, such as p53, p16INK4a, RAR-beta, and RASSF1. Point mutations within the K-RAS gene inactivate GTPase activity and the p21-RAS protein continuously transmits growth signals to the nucleus. Overexpression of c-erbB-2 or EGFR leads to a proliferative advantage. Inactivating mutation of p53 can lead to more rapid proliferation and reduced apoptosis. The protein encoded by the p16INK4a gene inhibits formation of CDK-cyclin-D complexes by competitive binding of CDK4 and CDK6. Loss of p16INK4a expression is a common feature of NSCLC RAR-beta is a nuclear receptor that bears vitamin-A-dependent transcriptional activity. RASSF1A is able to form heterodimers with Nore-1, an RAS effector. Therefore, loss of RASSF1A might shift the balance of RAS activity towards a growth-promoting effect." @default.
- NCIT_C91445 normalizedInformationContent "69.526842234962075" @default.
- NCIT_C91445 referenceCount "100" @default.
- NCIT_C91445 hasExactSynonym "NSCLC Pathway" @default.
- NCIT_C91445 hasExactSynonym "Non-Small Cell Lung Cancer Pathway" @default.
- NCIT_C91445 hasExactSynonym "Non-small cell lung cancer" @default.
- NCIT_C91445 type Class @default.
- NCIT_C91445 isDefinedBy ncit.owl @default.
- NCIT_C91445 label "Non-Small Cell Lung Cancer Pathway" @default.
- NCIT_C91445 subClassOf NCIT_C20633 @default.
- NCIT_C91445 subClassOf NCIT_C39701 @default.
- NCIT_C91445 subClassOf NCIT_C91436 @default.
- NCIT_C91445 subClassOf NCIT_C91445 @default.