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- NCIT_C91457 NCIT_NHC0 "C91457" @default.
- NCIT_C91457 NCIT_P106 "Functional Concept" @default.
- NCIT_C91457 NCIT_P108 "Base Excision Repair Pathway" @default.
- NCIT_C91457 NCIT_P207 "C2984269" @default.
- NCIT_C91457 NCIT_P215 "hsa03410" @default.
- NCIT_C91457 NCIT_P325 "Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates." @default.
- NCIT_C91457 normalizedInformationContent "73.853979692042088" @default.
- NCIT_C91457 referenceCount "52" @default.
- NCIT_C91457 hasExactSynonym "Base Excision Repair Pathway" @default.
- NCIT_C91457 hasExactSynonym "Base excision repair" @default.
- NCIT_C91457 type Class @default.
- NCIT_C91457 isDefinedBy ncit.owl @default.
- NCIT_C91457 label "Base Excision Repair Pathway" @default.
- NCIT_C91457 subClassOf NCIT_C20633 @default.
- NCIT_C91457 subClassOf NCIT_C39705 @default.
- NCIT_C91457 subClassOf NCIT_C91457 @default.