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- NCIT_C91462 NCIT_NHC0 "C91462" @default.
- NCIT_C91462 NCIT_P106 "Functional Concept" @default.
- NCIT_C91462 NCIT_P108 "Adherens Junction Assembly Pathway" @default.
- NCIT_C91462 NCIT_P207 "C2984274" @default.
- NCIT_C91462 NCIT_P215 "hsa04520" @default.
- NCIT_C91462 NCIT_P325 "Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion." @default.
- NCIT_C91462 normalizedInformationContent "68.836275093488439" @default.
- NCIT_C91462 referenceCount "111" @default.
- NCIT_C91462 hasExactSynonym "Adherens Junction Assembly Pathway" @default.
- NCIT_C91462 hasExactSynonym "Adherens junction" @default.
- NCIT_C91462 type Class @default.
- NCIT_C91462 isDefinedBy ncit.owl @default.
- NCIT_C91462 label "Adherens Junction Assembly Pathway" @default.
- NCIT_C91462 subClassOf NCIT_C17132 @default.
- NCIT_C91462 subClassOf NCIT_C20633 @default.
- NCIT_C91462 subClassOf NCIT_C91462 @default.