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- NCIT_C91463 NCIT_NHC0 "C91463" @default.
- NCIT_C91463 NCIT_P106 "Functional Concept" @default.
- NCIT_C91463 NCIT_P108 "Long-Term Depression Pathway" @default.
- NCIT_C91463 NCIT_P207 "C2984275" @default.
- NCIT_C91463 NCIT_P215 "hsa04730" @default.
- NCIT_C91463 NCIT_P325 "Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and Purkinje cells (PCs) induced by the conjunctive activation of PFs and climbing fiber (CF). Multiple signal transduction pathways have been shown to be involved in this process. Activation of PFs terminating on spines in dendritic branchlets leads to glutamate release and activation of both AMPA and mGluRs. Activation of CFs, which make multiple synaptic contacts on proximal dendrites, also via AMPA receptors, opens voltage-gated calcium channels (VGCCs) and causes a generalized influx of calcium. These cellular signals, generated from two different synaptic origins, trigger a cascade of events culminating in a phosphorylation-dependent, long-term reduction in AMPA receptor sensitivity at the PF-PC synapse. This may take place either through receptor internalization and/or through receptor desensitization." @default.
- NCIT_C91463 normalizedInformationContent "70.524861749516617" @default.
- NCIT_C91463 referenceCount "86" @default.
- NCIT_C91463 hasExactSynonym "Long-Term Depression Pathway" @default.
- NCIT_C91463 hasExactSynonym "Long-term depression" @default.
- NCIT_C91463 type Class @default.
- NCIT_C91463 isDefinedBy ncit.owl @default.
- NCIT_C91463 label "Long-Term Depression Pathway" @default.
- NCIT_C91463 subClassOf NCIT_C19779 @default.
- NCIT_C91463 subClassOf NCIT_C20633 @default.
- NCIT_C91463 subClassOf NCIT_C91463 @default.
- NCIT_C91463 subClassOf NCIT_C91822 @default.