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- NCIT_C91465 NCIT_NHC0 "C91465" @default.
- NCIT_C91465 NCIT_P106 "Functional Concept" @default.
- NCIT_C91465 NCIT_P108 "Chronic Myeloid Leukemia Pathway" @default.
- NCIT_C91465 NCIT_P207 "C2984277" @default.
- NCIT_C91465 NCIT_P215 "hsa05220" @default.
- NCIT_C91465 NCIT_P325 "Chronic myelogenous leukaemia (CML) is a biphasic disease, initiated by expression of the BCR/ABL fusion gene product in self-renewing, haematopoietic stem cells (HSCs). HSCs can differentiate into common myeloid progenitors (CMPs), which then differentiate into granulocyte/macrophage progenitors (GMPs). HSCs can also differentiate into common lymphoid progenitors (CLPs), which are the progenitors of lymphocytes such as T cells and B cells. The initial chronic phase of CML (CML-CP) is characterized by a massive expansion of the granulocytic-cell series. Acquisition of additional genetic mutations beyond expression of BCR/ABL causes the progression of CML from chronic phase to blast phase (CML-BP), characterized by an accumulation of myeloid or lymphoid blast cells." @default.
- NCIT_C91465 normalizedInformationContent "68.050265177258879" @default.
- NCIT_C91465 referenceCount "125" @default.
- NCIT_C91465 hasExactSynonym "CML Pathway" @default.
- NCIT_C91465 hasExactSynonym "Chronic Myeloid Leukemia Pathway" @default.
- NCIT_C91465 hasExactSynonym "Chronic myeloid leukemia" @default.
- NCIT_C91465 type Class @default.
- NCIT_C91465 isDefinedBy ncit.owl @default.
- NCIT_C91465 label "Chronic Myeloid Leukemia Pathway" @default.
- NCIT_C91465 subClassOf NCIT_C20633 @default.
- NCIT_C91465 subClassOf NCIT_C39701 @default.
- NCIT_C91465 subClassOf NCIT_C91436 @default.
- NCIT_C91465 subClassOf NCIT_C91465 @default.