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- NCIT_C91467 NCIT_NHC0 "C91467" @default.
- NCIT_C91467 NCIT_P106 "Functional Concept" @default.
- NCIT_C91467 NCIT_P108 "Cardiac Muscle Contraction Pathway" @default.
- NCIT_C91467 NCIT_P207 "C2984279" @default.
- NCIT_C91467 NCIT_P215 "hsa04260" @default.
- NCIT_C91467 NCIT_P325 "Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR." @default.
- NCIT_C91467 normalizedInformationContent "73.982472314446994" @default.
- NCIT_C91467 referenceCount "51" @default.
- NCIT_C91467 hasExactSynonym "Cardiac Muscle Contraction Pathway" @default.
- NCIT_C91467 hasExactSynonym "Cardiac muscle contraction" @default.
- NCIT_C91467 type Class @default.
- NCIT_C91467 isDefinedBy ncit.owl @default.
- NCIT_C91467 label "Cardiac Muscle Contraction Pathway" @default.
- NCIT_C91467 subClassOf NCIT_C19779 @default.
- NCIT_C91467 subClassOf NCIT_C20633 @default.
- NCIT_C91467 subClassOf NCIT_C91467 @default.
- NCIT_C91467 subClassOf NCIT_C91822 @default.