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- NCIT_C91468 NCIT_NHC0 "C91468" @default.
- NCIT_C91468 NCIT_P106 "Functional Concept" @default.
- NCIT_C91468 NCIT_P108 "Melanogenesis Pathway" @default.
- NCIT_C91468 NCIT_P207 "C2984280" @default.
- NCIT_C91468 NCIT_P215 "hsa04916" @default.
- NCIT_C91468 NCIT_P325 "Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents. The most important positive regulator of melanogenesis is the MC1 receptor with its ligands melanocortic peptides. MC1R activates the cyclic AMP (cAMP) response-element binding protein (CREB). Increased expression of MITF and its activation by phosphorylation (P) stimulate the transcription of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), which produce melanin. Melanin synthesis takes place within specialized intracellular organelles named melanosomes. Melanin-containing melanosomes then move from the perinuclear region to the dendrite tips and are transferred to keratinocytes by a still not well-characterized mechanism." @default.
- NCIT_C91468 normalizedInformationContent "67.945228652317667" @default.
- NCIT_C91468 referenceCount "127" @default.
- NCIT_C91468 hasExactSynonym "Melanogenesis Pathway" @default.
- NCIT_C91468 hasExactSynonym "Melanogenesis" @default.
- NCIT_C91468 type Class @default.
- NCIT_C91468 isDefinedBy ncit.owl @default.
- NCIT_C91468 label "Melanogenesis Pathway" @default.
- NCIT_C91468 subClassOf NCIT_C18611 @default.
- NCIT_C91468 subClassOf NCIT_C20633 @default.
- NCIT_C91468 subClassOf NCIT_C91468 @default.