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- NCIT_C91474 NCIT_NHC0 "C91474" @default.
- NCIT_C91474 NCIT_P106 "Functional Concept" @default.
- NCIT_C91474 NCIT_P108 "Pathogenic Escherichia coli Infection Pathway" @default.
- NCIT_C91474 NCIT_P207 "C2984286" @default.
- NCIT_C91474 NCIT_P215 "hsa05130" @default.
- NCIT_C91474 NCIT_P325 "Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections is induction of attaching and effacing (A/E) lesions that damage intestinal epithelial cells. The capacity to form A/E lesions is encoded mainly by the locus of enterocyte effacement (LEE) pathogenicity island. Tir, Map, EspF, EspG are known LEE-encoded effector proteins secreted via the type III secretion system, which is also LEE-encoded, into the host cell. EPEC and EHEC Tir's link the extracellular bacterium to the cell cytoskeleton. Map and EspF are involved in mitochondrion membrane permeabilization. EspG interacts with tubulins and stimulates microtubule destabilization. LEE-encoded adhesin or intimin (Eae) is exported via the general secretory pathway to the periplasm, where it is inserted into the outer membrane. In addition to Tir, two potential host cell-carried intimin receptors, beta1 integrin (ITGB1) and nucleolin (NCL), have so far been identified. The distinguishing feature of EHEC is the elaboration of Shiga-like toxin (Stx). Stx cleaves ribosomal RNA, thereby disrupting protein synthesis and killing the intoxicated epithelial or endothelial cells." @default.
- NCIT_C91474 normalizedInformationContent "72.690082634588421" @default.
- NCIT_C91474 referenceCount "62" @default.
- NCIT_C91474 hasExactSynonym "Pathogenic E. coli Infection Pathway" @default.
- NCIT_C91474 hasExactSynonym "Pathogenic Escherichia coli Infection Pathway" @default.
- NCIT_C91474 hasExactSynonym "Pathogenic Escherichia coli infection" @default.
- NCIT_C91474 type Class @default.
- NCIT_C91474 isDefinedBy ncit.owl @default.
- NCIT_C91474 label "Pathogenic Escherichia coli Infection Pathway" @default.
- NCIT_C91474 subClassOf NCIT_C20633 @default.
- NCIT_C91474 subClassOf NCIT_C39701 @default.
- NCIT_C91474 subClassOf NCIT_C39738 @default.
- NCIT_C91474 subClassOf NCIT_C91474 @default.