Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C91477> ?p ?o ?g. }
Showing items 1 to 17 of
17
with 100 items per page.
- NCIT_C91477 NCIT_NHC0 "C91477" @default.
- NCIT_C91477 NCIT_P106 "Functional Concept" @default.
- NCIT_C91477 NCIT_P108 "Melanoma Pathway" @default.
- NCIT_C91477 NCIT_P207 "C2984289" @default.
- NCIT_C91477 NCIT_P215 "hsa05218" @default.
- NCIT_C91477 NCIT_P325 "Five distinct stages have been proposed in the evolution of melanoma on the basis of histological criteria: common acquired and congenital nevi without dysplastic changes; dysplastic nevi with structural and architectural atypia; radial-growth phase (RGP) melanoma; vertical-growth phase (VGP) melanoma; and metastatic melanoma. Oncogenic NRAS mutations activate both effector pathways Raf-MEK-ERK and PI3K-Akt. The Raf-MEK-ERK pathway may also be activated via mutations in the BRAF gene. The PI3K-Akt pathway may be activated through loss or mutation of the inhibitory tumor suppressor gene PTEN. These mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. Moreover, melanoma development is strongly associated with inactivation of the p16INK4a/CDK4,6/pRb and p14ARF/HMD2/p53 tumor suppressor pathways. The vertical-growth phase and metastatic melanoma are notable for striking changes in the control of cell adhesion. Recently, amplification of the MITF gene was demonstrated in 10% of primary melanomas and 20% of metastatic melanomas, suggesting that MITF is a melanoma oncogene." @default.
- NCIT_C91477 normalizedInformationContent "68.602014802415724" @default.
- NCIT_C91477 referenceCount "115" @default.
- NCIT_C91477 hasExactSynonym "Melanoma Pathway" @default.
- NCIT_C91477 hasExactSynonym "Melanoma" @default.
- NCIT_C91477 type Class @default.
- NCIT_C91477 isDefinedBy ncit.owl @default.
- NCIT_C91477 label "Melanoma Pathway" @default.
- NCIT_C91477 subClassOf NCIT_C20633 @default.
- NCIT_C91477 subClassOf NCIT_C39701 @default.
- NCIT_C91477 subClassOf NCIT_C91436 @default.
- NCIT_C91477 subClassOf NCIT_C91477 @default.