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- NCIT_C91483 NCIT_NHC0 "C91483" @default.
- NCIT_C91483 NCIT_P106 "Functional Concept" @default.
- NCIT_C91483 NCIT_P108 "Homologous Recombination Pathway" @default.
- NCIT_C91483 NCIT_P207 "C2984295" @default.
- NCIT_C91483 NCIT_P215 "hsa03440" @default.
- NCIT_C91483 NCIT_P325 "Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR." @default.
- NCIT_C91483 normalizedInformationContent "73.853979692042088" @default.
- NCIT_C91483 referenceCount "52" @default.
- NCIT_C91483 hasExactSynonym "Homologous Recombination Pathway" @default.
- NCIT_C91483 hasExactSynonym "Homologous recombination" @default.
- NCIT_C91483 type Class @default.
- NCIT_C91483 isDefinedBy ncit.owl @default.
- NCIT_C91483 label "Homologous Recombination Pathway" @default.
- NCIT_C91483 subClassOf NCIT_C20633 @default.
- NCIT_C91483 subClassOf NCIT_C39705 @default.
- NCIT_C91483 subClassOf NCIT_C91483 @default.