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- NCIT_C91489 NCIT_NHC0 "C91489" @default.
- NCIT_C91489 NCIT_P106 "Functional Concept" @default.
- NCIT_C91489 NCIT_P108 "Insulin/Insulin Receptor Signaling Pathway" @default.
- NCIT_C91489 NCIT_P207 "C2984300" @default.
- NCIT_C91489 NCIT_P215 "hsa04910" @default.
- NCIT_C91489 NCIT_P325 "Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR." @default.
- NCIT_C91489 normalizedInformationContent "66.888075994929366" @default.
- NCIT_C91489 referenceCount "149" @default.
- NCIT_C91489 hasExactSynonym "Insulin signaling pathway" @default.
- NCIT_C91489 hasExactSynonym "Insulin/Insulin Receptor Signaling Pathway" @default.
- NCIT_C91489 type Class @default.
- NCIT_C91489 isDefinedBy ncit.owl @default.
- NCIT_C91489 label "Insulin/Insulin Receptor Signaling Pathway" @default.
- NCIT_C91489 subClassOf NCIT_C17132 @default.
- NCIT_C91489 subClassOf NCIT_C20633 @default.
- NCIT_C91489 subClassOf NCIT_C91489 @default.