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- NCIT_C91491 NCIT_NHC0 "C91491" @default.
- NCIT_C91491 NCIT_P106 "Functional Concept" @default.
- NCIT_C91491 NCIT_P108 "Leishmaniasis Infection Pathway" @default.
- NCIT_C91491 NCIT_P207 "C2984302" @default.
- NCIT_C91491 NCIT_P215 "hsa05140" @default.
- NCIT_C91491 NCIT_P325 "Leishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and proliferate intracellularly by deactivating the macrophage. Successful infection of Leishmania is achieved by alteration of signaling events in the host cell, leading to enhanced production of the autoinhibitory molecules like TGF-beta and decreased induction of cytokines such as IL12 for protective immunity. Nitric oxide production is also inhibited. In addition, defective expression of major histocompatibility complex (MHC) genes silences subsequent T cell activation mediated by macrophages, resulting in abnormal immune responses." @default.
- NCIT_C91491 normalizedInformationContent "68.65980697877589" @default.
- NCIT_C91491 referenceCount "114" @default.
- NCIT_C91491 hasExactSynonym "Leishmaniasis Infection Pathway" @default.
- NCIT_C91491 hasExactSynonym "Leishmaniasis" @default.
- NCIT_C91491 type Class @default.
- NCIT_C91491 isDefinedBy ncit.owl @default.
- NCIT_C91491 label "Leishmaniasis Infection Pathway" @default.
- NCIT_C91491 subClassOf NCIT_C20633 @default.
- NCIT_C91491 subClassOf NCIT_C39701 @default.
- NCIT_C91491 subClassOf NCIT_C39738 @default.
- NCIT_C91491 subClassOf NCIT_C91491 @default.