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- NCIT_C91492 NCIT_NHC0 "C91492" @default.
- NCIT_C91492 NCIT_P106 "Functional Concept" @default.
- NCIT_C91492 NCIT_P108 "Progesterone-Mediated Oocyte Maturation Pathway" @default.
- NCIT_C91492 NCIT_P207 "C2984303" @default.
- NCIT_C91492 NCIT_P215 "hsa04914" @default.
- NCIT_C91492 NCIT_P325 "Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP." @default.
- NCIT_C91492 normalizedInformationContent "69.593346936783348" @default.
- NCIT_C91492 referenceCount "99" @default.
- NCIT_C91492 hasExactSynonym "Progesterone-Mediated Oocyte Maturation Pathway" @default.
- NCIT_C91492 hasExactSynonym "Progesterone-mediated oocyte maturation" @default.
- NCIT_C91492 type Class @default.
- NCIT_C91492 isDefinedBy ncit.owl @default.
- NCIT_C91492 label "Progesterone-Mediated Oocyte Maturation Pathway" @default.
- NCIT_C91492 subClassOf NCIT_C20633 @default.
- NCIT_C91492 subClassOf NCIT_C39704 @default.
- NCIT_C91492 subClassOf NCIT_C91492 @default.