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- NCIT_C91494 NCIT_NHC0 "C91494" @default.
- NCIT_C91494 NCIT_P106 "Functional Concept" @default.
- NCIT_C91494 NCIT_P108 "Proximal Tubule Bicarbonate Reclamation Pathway" @default.
- NCIT_C91494 NCIT_P207 "C2984305" @default.
- NCIT_C91494 NCIT_P215 "hsa04964" @default.
- NCIT_C91494 NCIT_P325 "One of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating "new HCO3(-)" for regulating blood pH. In the tubular lumen, filtered HCO3(-) combines with H(+) in a reaction catalyzed by CA IV. The CO2 thus produced rapidly diffuses into the tubular cells and is combined with water to produce intracellular H(+) and HCO3(-), catalyzed by soluble cytoplasmic CA II. HCO3(-) is then cotransported with Na(+) into blood via the NBC-1. The intracellular H(+) produced by CA II is secreted into the tubular lumen predominantly via the NHE-3. The PT creates the "new HCO3(-)" by taking glutamine and metabolizing it to two molecules each of NH4(+) and HCO3(-). The NH4(+) is excreted into the tubular lumen, and the HCO3(-), which is "new HCO3(-)," is returned to the blood, where it replaces the HCO3(-) lost earlier in the titration of nonvolatile acids." @default.
- NCIT_C91494 normalizedInformationContent "82.080392758357064" @default.
- NCIT_C91494 referenceCount "15" @default.
- NCIT_C91494 hasExactSynonym "Proximal Tubule Bicarbonate Reclamation Pathway" @default.
- NCIT_C91494 hasExactSynonym "Proximal tubule bicarbonate reclamation" @default.
- NCIT_C91494 type Class @default.
- NCIT_C91494 isDefinedBy ncit.owl @default.
- NCIT_C91494 label "Proximal Tubule Bicarbonate Reclamation Pathway" @default.
- NCIT_C91494 subClassOf NCIT_C19779 @default.
- NCIT_C91494 subClassOf NCIT_C20633 @default.
- NCIT_C91494 subClassOf NCIT_C91494 @default.
- NCIT_C91494 subClassOf NCIT_C91822 @default.