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- NCIT_C91498 NCIT_NHC0 "C91498" @default.
- NCIT_C91498 NCIT_P106 "Functional Concept" @default.
- NCIT_C91498 NCIT_P108 "Peroxisome Biogenesis Pathway" @default.
- NCIT_C91498 NCIT_P207 "C2984308" @default.
- NCIT_C91498 NCIT_P215 "hsa04146" @default.
- NCIT_C91498 NCIT_P325 "Peroxisomes are essential organelles that play a key role in redox signaling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies." @default.
- NCIT_C91498 normalizedInformationContent "76.105970727550996" @default.
- NCIT_C91498 referenceCount "37" @default.
- NCIT_C91498 hasExactSynonym "Peroxisome Biogenesis Pathway" @default.
- NCIT_C91498 hasExactSynonym "Peroxisome" @default.
- NCIT_C91498 type Class @default.
- NCIT_C91498 isDefinedBy ncit.owl @default.
- NCIT_C91498 label "Peroxisome Biogenesis Pathway" @default.
- NCIT_C91498 subClassOf NCIT_C18611 @default.
- NCIT_C91498 subClassOf NCIT_C20633 @default.
- NCIT_C91498 subClassOf NCIT_C91498 @default.