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- NCIT_C91502 NCIT_NHC0 "C91502" @default.
- NCIT_C91502 NCIT_P106 "Functional Concept" @default.
- NCIT_C91502 NCIT_P108 "Small Cell Lung Cancer Pathway" @default.
- NCIT_C91502 NCIT_P207 "C2984312" @default.
- NCIT_C91502 NCIT_P215 "hsa05222" @default.
- NCIT_C91502 NCIT_P325 "Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 20% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumor suppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control." @default.
- NCIT_C91502 normalizedInformationContent "70.007054275464455" @default.
- NCIT_C91502 referenceCount "93" @default.
- NCIT_C91502 hasExactSynonym "SCLC Pathway" @default.
- NCIT_C91502 hasExactSynonym "Small Cell Lung Cancer Pathway" @default.
- NCIT_C91502 hasExactSynonym "Small cell lung cancer" @default.
- NCIT_C91502 type Class @default.
- NCIT_C91502 isDefinedBy ncit.owl @default.
- NCIT_C91502 label "Small Cell Lung Cancer Pathway" @default.
- NCIT_C91502 subClassOf NCIT_C20633 @default.
- NCIT_C91502 subClassOf NCIT_C39701 @default.
- NCIT_C91502 subClassOf NCIT_C91436 @default.
- NCIT_C91502 subClassOf NCIT_C91502 @default.