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- NCIT_C91503 NCIT_NHC0 "C91503" @default.
- NCIT_C91503 NCIT_P106 "Functional Concept" @default.
- NCIT_C91503 NCIT_P108 "Aldosterone-Regulated Sodium Reabsorption Pathway" @default.
- NCIT_C91503 NCIT_P207 "C2984313" @default.
- NCIT_C91503 NCIT_P215 "hsa04960" @default.
- NCIT_C91503 NCIT_P325 "Sodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-term blood pressure. Aldosterone plays a major role in sodium and potassium metabolism by binding to epithelial mineralocorticoid receptors (MR) in the renal collecting duct cells localized in the distal nephron, promoting sodium resorption and potassium excretion. Aldosterone enters a target cell and binds MR, which translocates into the nucleus and regulates gene transcription. Activation of MR leads to increased expression of Sgk-1, which phosphorylates Nedd4-2, an ubiquitin-ligase which targets ENAC to proteasomal degradation. Phosphorylated Nedd4-2 dissociates from ENAC, increasing its apical membrane abundance. Activation of MR also leads to increased expression of Na+/K+-ATPase, thus causing a net increase in sodium uptake from the renal filtrate. The specificity of MR for aldosterone is provided by 11beta-HSD2 by the rapid conversion of cortisol to cortisone in renal cortical collecting duct cells. Recently, besides genomic effects mediated by activated MR, rapid aldosterone actions that are independent of translation and transcription have been documented." @default.
- NCIT_C91503 normalizedInformationContent "75.111529024455209" @default.
- NCIT_C91503 referenceCount "43" @default.
- NCIT_C91503 hasExactSynonym "Aldosterone-Regulated Sodium Reabsorption Pathway" @default.
- NCIT_C91503 hasExactSynonym "Aldosterone-regulated sodium reabsorption" @default.
- NCIT_C91503 type Class @default.
- NCIT_C91503 isDefinedBy ncit.owl @default.
- NCIT_C91503 label "Aldosterone-Regulated Sodium Reabsorption Pathway" @default.
- NCIT_C91503 subClassOf NCIT_C19779 @default.
- NCIT_C91503 subClassOf NCIT_C20633 @default.
- NCIT_C91503 subClassOf NCIT_C91503 @default.
- NCIT_C91503 subClassOf NCIT_C91822 @default.