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- NCIT_C91505 NCIT_NHC0 "C91505" @default.
- NCIT_C91505 NCIT_P106 "Functional Concept" @default.
- NCIT_C91505 NCIT_P108 "Toll-Like Receptor Signaling Pathway" @default.
- NCIT_C91505 NCIT_P207 "C1817393" @default.
- NCIT_C91505 NCIT_P215 "hsa04620" @default.
- NCIT_C91505 NCIT_P325 "Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-kappa B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-kappa B and MAPK." @default.
- NCIT_C91505 normalizedInformationContent "66.334550188811178" @default.
- NCIT_C91505 referenceCount "162" @default.
- NCIT_C91505 hasExactSynonym "Toll-Like Receptor Signaling Pathway" @default.
- NCIT_C91505 hasExactSynonym "Toll-like receptor signaling pathway" @default.
- NCIT_C91505 type Class @default.
- NCIT_C91505 isDefinedBy ncit.owl @default.
- NCIT_C91505 label "Toll-Like Receptor Signaling Pathway" @default.
- NCIT_C91505 subClassOf NCIT_C17132 @default.
- NCIT_C91505 subClassOf NCIT_C20633 @default.
- NCIT_C91505 subClassOf NCIT_C91505 @default.