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- NCIT_C91508 NCIT_NHC0 "C91508" @default.
- NCIT_C91508 NCIT_P106 "Functional Concept" @default.
- NCIT_C91508 NCIT_P108 "Systemic Lupus Erythematosus Pathway" @default.
- NCIT_C91508 NCIT_P207 "C2984317" @default.
- NCIT_C91508 NCIT_P215 "hsa05322" @default.
- NCIT_C91508 NCIT_P325 "Systemic lupus erythematosus (SLE) is characterized by circulating IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components. Immune complexes comprising autoantibody and self-antigen is deposited particularly in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc-gamma-R-mediated neutrophil and macrophage activation. Activation of complement leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases." @default.
- NCIT_C91508 normalizedInformationContent "65.527985503481332" @default.
- NCIT_C91508 referenceCount "183" @default.
- NCIT_C91508 hasExactSynonym "SLE Pathway" @default.
- NCIT_C91508 hasExactSynonym "Systemic Lupus Erythematosus Pathway" @default.
- NCIT_C91508 hasExactSynonym "Systemic lupus erythematosus" @default.
- NCIT_C91508 type Class @default.
- NCIT_C91508 isDefinedBy ncit.owl @default.
- NCIT_C91508 label "Systemic Lupus Erythematosus Pathway" @default.
- NCIT_C91508 subClassOf NCIT_C20633 @default.
- NCIT_C91508 subClassOf NCIT_C39701 @default.
- NCIT_C91508 subClassOf NCIT_C91508 @default.