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- NCIT_C91513 NCIT_NHC0 "C91513" @default.
- NCIT_C91513 NCIT_P106 "Functional Concept" @default.
- NCIT_C91513 NCIT_P108 "Basal Cell Carcinoma Pathway" @default.
- NCIT_C91513 NCIT_P207 "C2984322" @default.
- NCIT_C91513 NCIT_P215 "hsa05217" @default.
- NCIT_C91513 NCIT_P325 "The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. Normally, ligand-dependent signaling by Hedgehog (Hh) homologs proceeds through binding to the Patched receptor. This binding relieves the Patched-mediated inhibition of signaling through the Smoothened (SMOH) gene product. This signaling ultimately results in the dissociation of the Gli1 transcription factor from an inhibitory complex in the cytoplasm, its subsequent translocation to the nucleus, and activation of target gene expression. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC." @default.
- NCIT_C91513 normalizedInformationContent "70.524861749516617" @default.
- NCIT_C91513 referenceCount "86" @default.
- NCIT_C91513 hasExactSynonym "Basal Cell Carcinoma Pathway" @default.
- NCIT_C91513 hasExactSynonym "Basal cell carcinoma" @default.
- NCIT_C91513 type Class @default.
- NCIT_C91513 isDefinedBy ncit.owl @default.
- NCIT_C91513 label "Basal Cell Carcinoma Pathway" @default.
- NCIT_C91513 subClassOf NCIT_C20633 @default.
- NCIT_C91513 subClassOf NCIT_C39701 @default.
- NCIT_C91513 subClassOf NCIT_C91436 @default.
- NCIT_C91513 subClassOf NCIT_C91513 @default.