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- NCIT_C91525 NCIT_NHC0 "C91525" @default.
- NCIT_C91525 NCIT_P106 "Functional Concept" @default.
- NCIT_C91525 NCIT_P108 "Chagas Disease Pathway" @default.
- NCIT_C91525 NCIT_P207 "C2984330" @default.
- NCIT_C91525 NCIT_P215 "hsa05142" @default.
- NCIT_C91525 NCIT_P325 "Trypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they invade diverse host cells including cardiomyocytes. Establishment of infection depends on various parasite molecules such as cruzipain, oligopeptidase B, and trans-sialidase that activate Ca2+ signaling. Internalized parasites escape from the parasitophorous vacuole using secreted pore-forming TcTOX molecule and replicate in the cytosol. Multiplied parasites eventually lyse infected host cells and are released in the circulation. During these events, the parasites manipulate host innate immunity and elicit cardiomyocyte hypertrophy. T lymphocyte responses are also disturbed." @default.
- NCIT_C91525 normalizedInformationContent "66.015589065990596" @default.
- NCIT_C91525 referenceCount "170" @default.
- NCIT_C91525 hasExactSynonym "Chagas Disease Pathway" @default.
- NCIT_C91525 hasExactSynonym "Chagas disease (American trypanosomiasis)" @default.
- NCIT_C91525 hasExactSynonym "Chagas disease" @default.
- NCIT_C91525 hasExactSynonym "T. cruzi Infection Pathway" @default.
- NCIT_C91525 hasExactSynonym "Trypanosoma cruzi Infection Pathway" @default.
- NCIT_C91525 type Class @default.
- NCIT_C91525 isDefinedBy ncit.owl @default.
- NCIT_C91525 label "Chagas Disease Pathway" @default.
- NCIT_C91525 subClassOf NCIT_C20633 @default.
- NCIT_C91525 subClassOf NCIT_C39701 @default.
- NCIT_C91525 subClassOf NCIT_C39738 @default.
- NCIT_C91525 subClassOf NCIT_C91525 @default.