Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C91526> ?p ?o ?g. }
Showing items 1 to 18 of
18
with 100 items per page.
- NCIT_C91526 NCIT_NHC0 "C91526" @default.
- NCIT_C91526 NCIT_P106 "Functional Concept" @default.
- NCIT_C91526 NCIT_P108 "Acute Myeloid Leukemia Pathway" @default.
- NCIT_C91526 NCIT_P207 "C2984331" @default.
- NCIT_C91526 NCIT_P215 "hsa05221" @default.
- NCIT_C91526 NCIT_P325 "Two major types of genetic events are crucial for the molecular pathogenesis of acute myeloid leukemias (AML): activating mutations of signal transduction intermediates and alterations in myeloid transcription factors governing hematopoietic differentiation. Both aberrant and constitutive activation of signal transduction molecules are found in about 50% of primary AML bone marrow samples, and seem to contribute to the increased proliferation and apoptosis resistance. The most common of these activating events were observed in the RTK Flt3, in N-Ras and K-Ras, in Kit, and sporadically in other RTKs. Specific haematopoietic transcription factors are crucial for differentiation to particular lineages during normal differentiation, but are frequently disrupted in AML. Some mechanisms of disruption involve the effect of fusion proteins that are generated by chromosomal translocations on haematopoietic transcription factors. In other cases, the transcription factors themselves are mutated." @default.
- NCIT_C91526 normalizedInformationContent "69.526842234962075" @default.
- NCIT_C91526 referenceCount "100" @default.
- NCIT_C91526 hasExactSynonym "AML Pathway" @default.
- NCIT_C91526 hasExactSynonym "Acute Myeloid Leukemia Pathway" @default.
- NCIT_C91526 hasExactSynonym "Acute myeloid leukemia" @default.
- NCIT_C91526 type Class @default.
- NCIT_C91526 isDefinedBy ncit.owl @default.
- NCIT_C91526 label "Acute Myeloid Leukemia Pathway" @default.
- NCIT_C91526 subClassOf NCIT_C20633 @default.
- NCIT_C91526 subClassOf NCIT_C39701 @default.
- NCIT_C91526 subClassOf NCIT_C91436 @default.
- NCIT_C91526 subClassOf NCIT_C91526 @default.