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- NCIT_C91530 NCIT_NHC0 "C91530" @default.
- NCIT_C91530 NCIT_P106 "Functional Concept" @default.
- NCIT_C91530 NCIT_P108 "Olfactory Transduction Pathway" @default.
- NCIT_C91530 NCIT_P207 "C2984335" @default.
- NCIT_C91530 NCIT_P215 "hsa04740" @default.
- NCIT_C91530 NCIT_P325 "A series of events in which cells in the nose bind to scent-bearing molecules and send electrical signals to the brain where they are perceived as smells." @default.
- NCIT_C91530 NCIT_P325 "Within the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be transmitted to the brain. Odorant molecules bind to a receptor protein (R) coupled to an olfactory specific Gs-protein (G) and activate a type III adenylyl cyclase (AC), increasing intracellular cAMP levels. cAMP targets an olfactory-specific cyclic-nucleotide gated ion channel (CNG), allowing cations, particularly Na and Ca, to flow down their electrochemical gradients into the cell, depolarizing the ORN. Furthermore, the Ca entering the cell is able to activate a Ca-activated Cl channel, which would allow Cl to flow out of the cell, thus further increasing the depolarization. Elevated intracellular Ca causes adaptation by at least two different molecular steps: inhibition of the activity of adenylyl cyclase via CAMKII-dependent phosphorylation and down-regulation of the affinity of the CNG channel to cAMP. Longer exposure to odorants can stimulate particulate guanylyl cyclase in cilia to produce cGMP and activate PKG, leading to a further increase in amount and duration of intracellular cAMP levels, which may serve to convert inactive forms of protein kinase A (PKA2) to active forms (PKA*). As part of a feedback loop, PKA can inhibit the activation of particulate guanylyl cyclase." @default.
- NCIT_C91530 normalizedInformationContent "75.757618607856713" @default.
- NCIT_C91530 referenceCount "39" @default.
- NCIT_C91530 hasExactSynonym "Olfactory Transduction Pathway" @default.
- NCIT_C91530 hasExactSynonym "Olfactory transduction" @default.
- NCIT_C91530 hasExactSynonym "olfactory transduction" @default.
- NCIT_C91530 type Class @default.
- NCIT_C91530 isDefinedBy ncit.owl @default.
- NCIT_C91530 label "Olfactory Transduction Pathway" @default.
- NCIT_C91530 subClassOf NCIT_C17132 @default.
- NCIT_C91530 subClassOf NCIT_C20633 @default.
- NCIT_C91530 subClassOf NCIT_C91530 @default.