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- NCIT_C91531 NCIT_NHC0 "C91531" @default.
- NCIT_C91531 NCIT_P106 "Functional Concept" @default.
- NCIT_C91531 NCIT_P108 "Wnt Signaling Pathway KEGG" @default.
- NCIT_C91531 NCIT_P207 "C2984336" @default.
- NCIT_C91531 NCIT_P215 "hsa04310" @default.
- NCIT_C91531 NCIT_P325 "Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin." @default.
- NCIT_C91531 normalizedInformationContent "65.107707000276349" @default.
- NCIT_C91531 referenceCount "195" @default.
- NCIT_C91531 hasExactSynonym "Wnt Signaling Pathway KEGG" @default.
- NCIT_C91531 hasExactSynonym "Wnt signaling pathway" @default.
- NCIT_C91531 type Class @default.
- NCIT_C91531 isDefinedBy ncit.owl @default.
- NCIT_C91531 label "Wnt Signaling Pathway KEGG" @default.
- NCIT_C91531 subClassOf NCIT_C17132 @default.
- NCIT_C91531 subClassOf NCIT_C20633 @default.
- NCIT_C91531 subClassOf NCIT_C91531 @default.