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- NCIT_C91704 IAO_0000115 "An oral traditional Chinese herbal formulation in powder form containing a spray-dried preparation of an aqueous extract from the four herbs Scutellaria baicalensis, Glycyrrhiza uralensis, Ziziphus jujuba and Paeonia lactiflora, with potential immunomodulating and chemoprotective activities, and which may be used as an adjuvant for chemotherapeutic agents. Although the mechanisms of action remain to be fully elucidated, PHY906 possesses a wide range of pharmacological activities such as the enhancement of oral uptake of pharmacologically active agents, inhibition of CYP3A4, modulation of certain pro-inflammatory cytokines, enhanced migration of macrophages and lymphocytes, and the inhibition of expression of matrix metalloproteinase (MMP), nuclear factor kappaB (NF-kB), cyclooxygenase (COX), nitric oxide synthase (NOS), beta-glucuronidase, the neurokinin 1 receptor (NK1R; tachykinin receptor 1; TACR1; substance-P receptor) and the delta-opioid receptor. PHY906 may also enhance the anti-tumor effect of other anti-cancer agents, and may protect the gastrointestinal (GI) mucosa against damage and reduce GI symptoms." @default.
- NCIT_C91704 NCIT_NHC0 "C91704" @default.
- NCIT_C91704 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C91704 NCIT_P107 "Chinese Herbal Formulation PHY906" @default.
- NCIT_C91704 NCIT_P108 "Chinese Herbal Formulation PHY906" @default.
- NCIT_C91704 NCIT_P207 "C1260030" @default.
- NCIT_C91704 NCIT_P322 "CTRP" @default.
- NCIT_C91704 NCIT_P329 "357577" @default.
- NCIT_C91704 NCIT_P330 "357577" @default.
- NCIT_C91704 NCIT_P399 "357577" @default.
- NCIT_C91704 normalizedInformationContent "100" @default.
- NCIT_C91704 referenceCount "1" @default.
- NCIT_C91704 hasExactSynonym "Chinese Herbal Formulation PHY906" @default.
- NCIT_C91704 hasExactSynonym "KD-018" @default.
- NCIT_C91704 hasExactSynonym "KD018" @default.
- NCIT_C91704 hasExactSynonym "PHY906" @default.
- NCIT_C91704 hasExactSynonym "TCM PHY906" @default.
- NCIT_C91704 hasExactSynonym "YIV 906" @default.
- NCIT_C91704 hasExactSynonym "YIV-906" @default.
- NCIT_C91704 hasExactSynonym "YIV906" @default.
- NCIT_C91704 inSubset NCIT_C116977 @default.
- NCIT_C91704 inSubset NCIT_C116978 @default.
- NCIT_C91704 inSubset NCIT_C176424 @default.
- NCIT_C91704 type Class @default.
- NCIT_C91704 isDefinedBy ncit.owl @default.
- NCIT_C91704 label "Chinese Herbal Formulation PHY906" @default.
- NCIT_C91704 subClassOf NCIT_C1908 @default.
- NCIT_C91704 subClassOf NCIT_C1909 @default.
- NCIT_C91704 subClassOf NCIT_C210 @default.
- NCIT_C91704 subClassOf NCIT_C2140 @default.
- NCIT_C91704 subClassOf NCIT_C2141 @default.
- NCIT_C91704 subClassOf NCIT_C308 @default.
- NCIT_C91704 subClassOf NCIT_C91704 @default.