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- NCIT_C91707 IAO_0000115 "An irradiated, autologous pancreatic cancer vaccine consisting of patient-specific pancreatic cancer cells genetically modified to secrete the cytokine granulocyte-macrophage colony stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic activities. Upon vaccination, GVAX pancreatic cancer vaccine secretes GM-CSF. In turn, GM-CSF may stimulate the body's immune system against tumor cells by enhancing the activation of dendritic cells (DCs) and promoting antigen presentation to both B- and T-cells. In addition, GM-CSF promotes antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function." @default.
- NCIT_C91707 NCIT_NHC0 "C91707" @default.
- NCIT_C91707 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C91707 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C91707 NCIT_P107 "Autologous GM-CSF-secreting Lethally Irradiated Pancreatic Cancer Vaccine" @default.
- NCIT_C91707 NCIT_P108 "Autologous GM-CSF-secreting Lethally Irradiated Pancreatic Cancer Vaccine" @default.
- NCIT_C91707 NCIT_P208 "CL554538" @default.
- NCIT_C91707 NCIT_P322 "CTRP" @default.
- NCIT_C91707 NCIT_P329 "368623" @default.
- NCIT_C91707 NCIT_P330 "368623" @default.
- NCIT_C91707 NCIT_P399 "368623" @default.
- NCIT_C91707 normalizedInformationContent "100" @default.
- NCIT_C91707 referenceCount "1" @default.
- NCIT_C91707 hasExactSynonym "Autologous GM-CSF-secreting Lethally Irradiated Pancreatic Cancer Vaccine" @default.
- NCIT_C91707 hasExactSynonym "Autologous GVAX Pancreatic Cancer Vaccine" @default.
- NCIT_C91707 inSubset NCIT_C116977 @default.
- NCIT_C91707 inSubset NCIT_C116978 @default.
- NCIT_C91707 inSubset NCIT_C128784 @default.
- NCIT_C91707 inSubset NCIT_C176424 @default.
- NCIT_C91707 type Class @default.
- NCIT_C91707 isDefinedBy ncit.owl @default.
- NCIT_C91707 label "Autologous GM-CSF-secreting Lethally Irradiated Pancreatic Cancer Vaccine" @default.
- NCIT_C91707 subClassOf NCIT_C129820 @default.
- NCIT_C91707 subClassOf NCIT_C142078 @default.
- NCIT_C91707 subClassOf NCIT_C154231 @default.
- NCIT_C91707 subClassOf NCIT_C1663 @default.
- NCIT_C91707 subClassOf NCIT_C1908 @default.
- NCIT_C91707 subClassOf NCIT_C1909 @default.
- NCIT_C91707 subClassOf NCIT_C1962 @default.
- NCIT_C91707 subClassOf NCIT_C1978 @default.
- NCIT_C91707 subClassOf NCIT_C2341 @default.
- NCIT_C91707 subClassOf NCIT_C274 @default.
- NCIT_C91707 subClassOf NCIT_C307 @default.
- NCIT_C91707 subClassOf NCIT_C308 @default.
- NCIT_C91707 subClassOf NCIT_C91707 @default.
- NCIT_C91707 subClassOf NCIT_C923 @default.