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- NCIT_C91724 IAO_0000115 "An MDM2 (human homolog of double minutes-2; HDM2) antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival." @default.
- NCIT_C91724 NCIT_A32 NCIT_C1909 @default.
- NCIT_C91724 NCIT_A7 NCIT_C17515 @default.
- NCIT_C91724 NCIT_NHC0 "C91724" @default.
- NCIT_C91724 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C91724 NCIT_P107 "MDM2 Antagonist RO5045337" @default.
- NCIT_C91724 NCIT_P108 "MDM2 Antagonist RO5045337" @default.
- NCIT_C91724 NCIT_P208 "CL421615" @default.
- NCIT_C91724 NCIT_P210 "939981-39-2" @default.
- NCIT_C91724 NCIT_P319 "Q8MI0X869M" @default.
- NCIT_C91724 NCIT_P322 "CTRP" @default.
- NCIT_C91724 NCIT_P322 "FDA" @default.
- NCIT_C91724 NCIT_P322 "GDC" @default.
- NCIT_C91724 NCIT_P329 "581121" @default.
- NCIT_C91724 NCIT_P330 "581121" @default.
- NCIT_C91724 NCIT_P375 "MDM2 Antagonist RO5045337" @default.
- NCIT_C91724 NCIT_P399 "581121" @default.
- NCIT_C91724 normalizedInformationContent "100" @default.
- NCIT_C91724 referenceCount "1" @default.
- NCIT_C91724 hasExactSynonym "MDM2 Antagonist RO5045337" @default.
- NCIT_C91724 hasExactSynonym "R7112" @default.
- NCIT_C91724 hasExactSynonym "RO-5045337" @default.
- NCIT_C91724 hasExactSynonym "RO5045337" @default.
- NCIT_C91724 inSubset NCIT_C116977 @default.
- NCIT_C91724 inSubset NCIT_C116978 @default.
- NCIT_C91724 inSubset NCIT_C128784 @default.
- NCIT_C91724 inSubset NCIT_C157711 @default.
- NCIT_C91724 inSubset NCIT_C157712 @default.
- NCIT_C91724 inSubset NCIT_C176424 @default.
- NCIT_C91724 inSubset NCIT_C177537 @default.
- NCIT_C91724 inSubset NCIT_C63923 @default.
- NCIT_C91724 type Class @default.
- NCIT_C91724 isDefinedBy ncit.owl @default.
- NCIT_C91724 label "MDM2 Antagonist RO5045337" @default.
- NCIT_C91724 subClassOf NCIT_C129839 @default.
- NCIT_C91724 subClassOf NCIT_C162996 @default.
- NCIT_C91724 subClassOf NCIT_C1908 @default.
- NCIT_C91724 subClassOf NCIT_C1909 @default.
- NCIT_C91724 subClassOf NCIT_C274 @default.
- NCIT_C91724 subClassOf NCIT_C91724 @default.