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- NCIT_C91732 IAO_0000115 "An agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. Upon intravenous administration, gedatolisib inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K." @default.
- NCIT_C91732 NCIT_A32 NCIT_C1909 @default.
- NCIT_C91732 NCIT_A7 NCIT_C17270 @default.
- NCIT_C91732 NCIT_NHC0 "C91732" @default.
- NCIT_C91732 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C91732 NCIT_P107 "Gedatolisib" @default.
- NCIT_C91732 NCIT_P108 "Gedatolisib" @default.
- NCIT_C91732 NCIT_P207 "C2933603" @default.
- NCIT_C91732 NCIT_P210 "1197160-78-3" @default.
- NCIT_C91732 NCIT_P319 "96265TNH2R" @default.
- NCIT_C91732 NCIT_P322 "CTRP" @default.
- NCIT_C91732 NCIT_P322 "FDA" @default.
- NCIT_C91732 NCIT_P322 "GDC" @default.
- NCIT_C91732 NCIT_P329 "651189" @default.
- NCIT_C91732 NCIT_P330 "651189" @default.
- NCIT_C91732 NCIT_P375 "Gedatolisib" @default.
- NCIT_C91732 NCIT_P399 "651189" @default.
- NCIT_C91732 normalizedInformationContent "100" @default.
- NCIT_C91732 referenceCount "1" @default.
- NCIT_C91732 hasExactSynonym "1-(4-[[4-(dimethylamino)piperidin-1-yl]carbonyl]phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea" @default.
- NCIT_C91732 hasExactSynonym "GEDATOLISIB" @default.
- NCIT_C91732 hasExactSynonym "Gedatolisib" @default.
- NCIT_C91732 hasExactSynonym "PF 05212384" @default.
- NCIT_C91732 hasExactSynonym "PF-05212384" @default.
- NCIT_C91732 hasExactSynonym "PKI 587" @default.
- NCIT_C91732 hasExactSynonym "PKI-587" @default.
- NCIT_C91732 hasExactSynonym "Urea, N-(4-((4-(dimethylamino)-1-piperidinyl)carbonyl)phenyl)-N'-(4-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)phenyl)-" @default.
- NCIT_C91732 inSubset NCIT_C116977 @default.
- NCIT_C91732 inSubset NCIT_C116978 @default.
- NCIT_C91732 inSubset NCIT_C128784 @default.
- NCIT_C91732 inSubset NCIT_C157711 @default.
- NCIT_C91732 inSubset NCIT_C157712 @default.
- NCIT_C91732 inSubset NCIT_C176424 @default.
- NCIT_C91732 inSubset NCIT_C177537 @default.
- NCIT_C91732 inSubset NCIT_C63923 @default.
- NCIT_C91732 type Class @default.
- NCIT_C91732 isDefinedBy ncit.owl @default.
- NCIT_C91732 label "Gedatolisib" @default.
- NCIT_C91732 subClassOf NCIT_C129824 @default.
- NCIT_C91732 subClassOf NCIT_C129825 @default.
- NCIT_C91732 subClassOf NCIT_C1404 @default.
- NCIT_C91732 subClassOf NCIT_C163758 @default.
- NCIT_C91732 subClassOf NCIT_C1742 @default.
- NCIT_C91732 subClassOf NCIT_C1908 @default.
- NCIT_C91732 subClassOf NCIT_C1909 @default.
- NCIT_C91732 subClassOf NCIT_C2152 @default.
- NCIT_C91732 subClassOf NCIT_C2189 @default.
- NCIT_C91732 subClassOf NCIT_C274 @default.
- NCIT_C91732 subClassOf NCIT_C471 @default.
- NCIT_C91732 subClassOf NCIT_C91732 @default.