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- NCIT_C91805 NCIT_NHC0 "C91805" @default.
- NCIT_C91805 NCIT_P106 "Functional Concept" @default.
- NCIT_C91805 NCIT_P108 "Phototransduction Pathway" @default.
- NCIT_C91805 NCIT_P207 "C2984570" @default.
- NCIT_C91805 NCIT_P215 "hsa04744" @default.
- NCIT_C91805 NCIT_P325 "Phototransduction is a biochemical process by which the photoreceptor cells generate electrical signals in response to captured photons. The vertebrate cascade starts with the absorption of photons by the photoreceptive pigments, the rhodopsins, which consist of a membrane embedded chromophore, 11-cis-retinal, and a G-protein-coupled receptor, opsin. The photon isomerizes 11-cis-retinal to all-trans-retinal which induces a structural change that activates the opsin. This triggers hydrolysis of cGMP by activating a transducin-phosphodiesterase 6 (PDE6) cascade, which results in closure of the cGMP-gated cation channels (CNG) in the plasma membrane and membrane hyperpolarization. The hyperpolarization of the membrane potential of the photoreceptor cell modulates the release of neurotransmitters to downstream cells. Recovery from light involves the deactivation of the light-activated intermediates: photolyzed rhodopsin is phosphorylated by rhodopsin kinase (RK) and subsequently capped off by arrestin; GTP-binding transducin alpha subunit deactivates through a process that is stimulated by RGS9." @default.
- NCIT_C91805 normalizedInformationContent "85.460608731874885" @default.
- NCIT_C91805 referenceCount "9" @default.
- NCIT_C91805 hasExactSynonym "Phototransduction Pathway" @default.
- NCIT_C91805 hasExactSynonym "Phototransduction" @default.
- NCIT_C91805 type Class @default.
- NCIT_C91805 isDefinedBy ncit.owl @default.
- NCIT_C91805 label "Phototransduction Pathway" @default.
- NCIT_C91805 subClassOf NCIT_C17132 @default.
- NCIT_C91805 subClassOf NCIT_C20633 @default.
- NCIT_C91805 subClassOf NCIT_C91805 @default.